ASD

GO:0043405 regulation of MAP kinase activity (205)

GeneInput weightStandardRank
PPP2CA--20
KRAS--157
HTR2A0.251121
RGS4--178
NF10.251372
DUSP8--438
MAP3K9--462
TRIB2--472
SPAG9--558
MAPK8IP1--1605
UCHL1--1675
MADD--759
TAB2--785
SPRED2--811
MAP2K10.251907
GNG3--927
SPRED1--962
GRM10.251975
MAPK1--1128
BMP7--1137
PPP2R1A--1163
GAB1--1198
MAP3K5--1220
MAP2K20.2511240
PDCD10--1274
MAP3K7--1275
ADRA2A0.2511399
SPRY2--1454
EDN3--11577
CHRNA70.511837
TGFA--1873
MAPK11--1962
PKN1--1967
DUSP5--2022
GPS1--2023
DVL3--2090
MAPK8IP3--2274
DUSP6--2466
HMGCR--2526
EGFR--12546
SOD1--12702
PDCD4--2707
MAP4K5--2894
FZD10--2957
MAP3K10--2968
PTK2B--3063
MAP3K2--3184
SPRY4--3196
WNT5A--3319
MAP3K1--13381
TRIB1--3431
DAB2IP--3482
TAB3--3641
MAP3K4--3663
PDGFA--3731
DUSP1--3785
NOX4--3804
MAPKAPK2--3870
MAPK14--3975
DUSP4--4019
VEGFA0.2514087
PDE6H--4126
LPAR1--4170
AXIN1--14419
FGF10--14532
PROK2--14655
INPPL1--4681
PAK1--4940
CBS0.2515018
RGS2--5095
DUSP10--5172
DUSP16--5189
TNFRSF11A--15293
HGF0.2515313
CXCR4--5414
PRDX2--5497
MAP2K7--5837
INSR--15872
ADIPOQ0.2516032
PLA2G1B--6059
DUSP19--6060
TDGF1--6132
ZEB2--6361
MAPK30.2516426
LPAR2--6450
BMP4--16499
PRKCD--6504
DVL2--6546
UBC--6756
PLCE1--6929
HTR2B--6992
DRD40.2517021
WNT7B--7113
FRS2--7173
TAB1--7218
ILK--7305
WNT7A--7312
GRM4--7321
FGD4--17457
PPEF2--7509
GH1--7858
MET1.018002
CD24--18102
HIPK3--8282
DUSP3--8506
DAXX--8508
ADRA2C--8551
DUSP2--8596
DUSP7--8625
GSTP10.2518742
NUP62--18755
PROK1--9002
PTPRJ--19136
GHRL0.2519242
TSC20.2519351
EDN1--9540
C1QTNF2--10034
SHC1--10045
GHR--110098
ADRA2B--10119
MAP2K6--10478
LAX1--10483
SPRY1--10636
IL1B--110818
TLR6--10981
TRAF6--11055
PIK3CB--11542
ZNF675--11676
CDK12--11802
STK380.25111822
LPAR3--11897
SPRED3--12062
CD81--112160
EPGN--12503
TLR4--112795
EGF0.25112881
MAP3K11--12938
RGS14--12999
TGFB3--113097
FGF2--13150
TLR9--13360
MDFI--13519
DUSP9--13685
MAP2K3--13704
MBIP--14010
CCL19--14578
IRAK3--14633
IRAK2--15024
TNF0.25115243
CAV3--115414
ITGA1--15500
ELANE--115526
GPS2--17956
AJUBA--18146
PSEN1--18523
TP73--18810
IQGAP3--19438
UBB--19448
ADORA2B--19522
BIRC7--19826
TGFB10.25120135
PTPLAD1--20272
PDE6G--120364
MAP4K2--20522
RIPK2--20830
TRIB3--20863
PDGFB--21071
C5AR1--21363
FPR1--21375
EFNA1--21477
CBLC--21497
NOD2--121514
IRAK1--21640
MDFIC--21692
ADAM8--21797
C5--122004
MAP4K1--22336
DBNL--22402
TPD52L1--22519
S1PR2--22592
RIPK1--22681
PRKAA1--22917
MUL1--22953
ERBB2--123130
PDGFRB--23242
RGS3--23349
NOD1--23388
APOE0.25123516
IKBKG--123539
GBA--123666
TRAF2--23686
AVPI1--23843
SYK--23906
CD74--24030
MAPKAPK3--24170
MAP3K6--24220
RPS27A--24381
UBA52--24384
THBS1--24444
DUSP22--24825
CDK1--25053
SMPD1--125116
AIDA--25211
CAV1--125381
IL1RN0.25125385

Network

GO:0043405

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  Ensembl: ENSG00000133703  HGNC: 6407  HPRD: 01817 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HPRD: 01638  Ensembl: ENSG00000102468  HGNC: 5293 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
NF1neurofibromin 1 Entrez:4763  HGNC: 7765  HPRD: 01203  Ensembl: ENSG00000196712 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
KRASKirsten rat sarcoma viral oncogene homolog
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
RGS4regulator of G-protein signaling 4
NF1neurofibromin 1
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
KRASKRASKirsten rat sarcoma viral oncogene homolog
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
RGS4RGS4regulator of G-protein signaling 4
NF1NF1neurofibromin 1

Troyanskaya Laboratory - Princeton University