ASD

GO:0030837 negative regulation of actin filament polymerization (34)

GeneInput weightStandardRank
PFN2--551
SLIT2--659
KANK1--1150
SPTAN1--11287
DMTN--1465
SPTBN4--1647
SPTBN2--11935
TMSB10--2139
CAPZB--2179
ADD2--2388
ADD1--12876
TMSB15A--2947
TMSB15B--3139
SPTB--3478
SPTBN1--3627
CAPZA2--4483
RDX--14697
CAPZA1--4983
SPTBN5--5319
TMSB4X--6302
SPTA1--16958
AVIL--7943
CAPZA3--8396
SCIN--9620
TWF1--11060
TMSB4Y--13524
TMSB4XP8--14081
TMSB4XP4--17717
CAPG--20663
VIL10.5122243
VILL--22283
TWF2--23010
GSN--124007
TRIOBP--124113

Network

GO:0030837

Network
Enrichment
NameDescriptionExternal IDs
PFN2profilin 2 Entrez:5217  Ensembl: ENSG00000070087  HGNC: 8882  HPRD: 01451 
SLIT2slit homolog 2 (Drosophila) Entrez:9353  Ensembl: ENSG00000145147  HPRD: 04776  HGNC: 11086 
KANK1KN motif and ankyrin repeat domains 1 Entrez:23189  HPRD: 09651  HGNC: 19309  Ensembl: ENSG00000107104 
SPTAN1spectrin, alpha, non-erythrocytic 1 Entrez:6709  HGNC: 11273  Ensembl: ENSG00000197694  HPRD: 01684 
DMTNdematin actin binding protein Entrez:2039  HPRD: 00506  Ensembl: ENSG00000158856  HGNC: 3382 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PFN2profilin 2
SLIT2slit homolog 2 (Drosophila)
KANK1KN motif and ankyrin repeat domains 1
SPTAN1spectrin, alpha, non-erythrocytic 1
DMTNdematin actin binding protein
Query geneGeneGene descriptionEdge score
PFN2PFN2profilin 2
SLIT2SLIT2slit homolog 2 (Drosophila)
KANK1KANK1KN motif and ankyrin repeat domains 1
SPTAN1SPTAN1spectrin, alpha, non-erythrocytic 1
DMTNDMTNdematin actin binding protein

Troyanskaya Laboratory - Princeton University