ASD

GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (55)

GeneInput weightStandardRank
TRIM33--1147
SFRP1--387
NR3C1--496
PEG10--627
CHRD--941
HIPK2--1051
SMAD7--1192
ONECUT2--1700
STRAP--1732
LEMD3--12084
FBN2--2131
SMAD6--2305
BCL9L--2729
NOTCH1--12865
SKIL--2889
SKI--2904
SOSTDC1--3003
SMURF1--3060
WNT5A--3319
BMPER--3497
GREM1--3867
NKX2-1--4142
GLG1--4233
PRDM16--4345
WNT1--4383
SFRP2--5252
NOG--15439
ACVR1--16054
ADAMTSL2--6151
CIDEA--6211
TGFBR3--6672
SOST--6885
CER1--6956
PIN1--7940
BAMBI--8550
VWC2--8879
CHST11--9003
FBN1--110976
DKK1--11567
ASPN--11718
DAND5--12647
SKOR2--12780
SKOR1--12870
TGFB3--113097
FST--14783
HSPA5--19143
FZD1--20775
EID2--21599
SNX6--22713
TGFB1I1--23709
LTBP1--24489
ENG--124746
TWSG1--24840
FSTL3--25154
CAV1--125381

Network

GO:0090101

Network
Enrichment
NameDescriptionExternal IDs
TRIM33tripartite motif containing 33 Entrez:51592  HPRD: 10423  HGNC: 16290  Ensembl: ENSG00000197323 
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Entrez:2908  HPRD: 00679  HGNC: 7978  Ensembl: ENSG00000113580 
PEG10paternally expressed 10 Entrez:23089  Ensembl: ENSG00000242265  HGNC: 14005 
CHRDchordin Entrez:8646  Ensembl: ENSG00000090539  HGNC: 1949  HPRD: 04592 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
TRIM33tripartite motif containing 33
SFRP1secreted frizzled-related protein 1
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PEG10paternally expressed 10
CHRDchordin
Query geneGeneGene descriptionEdge score
TRIM33TRIM33tripartite motif containing 33
SFRP1SFRP1secreted frizzled-related protein 1
NR3C1NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PEG10PEG10paternally expressed 10
CHRDCHRDchordin

Troyanskaya Laboratory - Princeton University