GO:0043409 negative regulation of MAPKKK cascade (66)

GeneInput weightStandardRank
PPP2CA--21
RGS4--99
AKT10.251303
MAPK8IP1--1326
NF10.251333
APC0.251528
IGF1R--631
SPRED2--643
DUSP8--796
PPP2R1A--852
SPRED1--1282
DUSP5--1317
SPRY2--1552
NCOR1--1807
DUSP6--1889
IGF10.2511993
PSMD10--2012
GPS1--2030
DUSP1--2140
KLF4--3003
SFRP4--3511
DAG1--3662
DUSP4--4300
MECOM--4397
TAOK3--4471
NF2--14798
ADIPOQ0.2514834
DUSP19--5073
DUSP3--5845
DUSP10--6196
PPEF2--6387
P2RX7--6517
MEN1--16723
FOXO10.2516970
TLR4--17283
DUSP7--7411
DUSP9--7653
DUSP2--7903
PIN1--8222
DUSP16--9952
GSTP10.25110429
SPRY1--10579
CAV3--110580
MBIP--10795
ITCH--10863
LAX1--10896
PEBP1--11226
RGS14--11308
FKTN--112941
NDRG2--14228
AMBP--14902
ZNF675--15034
F2RL1--15088
CNKSR3--16330
HDAC3--19605
SPRED3--19822
GPS2--20293
LIF--20888
SLC9A3R1--21807
RGS3--21940
VRK3--22754
CAV1--124767
AIDA--25079
FOXM1--25108
DUSP22--25132
IGBP1--25575

Network

GO:0043409

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
AKT1v-akt murine thymoma viral oncogene homolog 1 Entrez:207  HPRD: 01261  Ensembl: ENSG00000142208  HGNC: 391 
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1 Entrez:9479  HPRD: 05223  Ensembl: ENSG00000121653  HGNC: 6882 
NF1neurofibromin 1 Entrez:4763  HGNC: 7765  HPRD: 01203  Ensembl: ENSG00000196712 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4regulator of G-protein signaling 4
AKT1v-akt murine thymoma viral oncogene homolog 1
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1
NF1neurofibromin 1
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4RGS4regulator of G-protein signaling 4
AKT1AKT1v-akt murine thymoma viral oncogene homolog 1
MAPK8IP1MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1
NF1NF1neurofibromin 1