ASD

GO:0051241 negative regulation of multicellular organismal process (269)

GeneInput weightStandardRank
HTR2A0.25151
ADNP0.5191
GRIK20.51142
SFRP1--204
GRIK1--216
SLC6A10.251238
CRH--328
GABBR10.251352
CALCA--460
DRD50.251482
ADORA1--498
NPY5R0.251512
TAC10.251543
TGFB2--625
RAPGEF40.251635
STXBP1--659
UBE2D3--661
DRD10.251662
CX3CL1--832
ADRB1--866
ADRA1A--937
BMPR2--1964
GRIK30.251976
SOX9--11045
PIK3R10.2511065
RAC1--1087
PTCH1--11149
CARTPT0.2511181
ACHE--1266
TSPO0.2511277
GNAI3--1340
AGTR20.2511418
GFRA4--1498
ATP1A2--11611
GNAI1--1613
CHRNA70.511657
SLC24A2--1691
FKBP1B--1700
GUCY1A3--1730
LEF1--1731
TBX5--1743
HRG--1850
DRD20.2512071
GHSR0.2512085
RBP4--2097
BCHE--2123
GLRA1--2146
GSK3A--2346
BCOR--12451
TNR--2784
IL12B--2797
PRNP--12842
SERPINE2--2896
FGF23--12939
KLF4--3003
AVPR1A0.513141
PTGS20.2513176
PTK2B--3191
BMP10--3196
IFNB1--3220
HS3ST5--3306
SLC6A40.2513328
SOD1--13330
NOTCH1--13360
CYBA--13439
MGEA5--3440
STATH--3528
NGFR0.2513554
TNFAIP3--3628
RGS2--3677
MSTN--3712
ADRA1D--3761
CXADR--3781
AGT--13783
CD83--3832
PLAUR--3929
BCL6--3994
ATP1A10.2514084
NDFIP1--4331
IRF3--4434
OXTR0.514494
WNT11--4528
AVPR2--14537
IL6--14578
KAT5--4613
PDGFA--4678
CST3--14680
VEGFA0.2514691
SMURF1--4696
F11--14721
SOX8--4770
PLG--4815
ADIPOQ0.2514834
ADRBK1--4864
FURIN--4868
CIITA--15009
KNG1--5045
BMP4--15180
CIDEA--5234
IFNG--15255
TGFB3--15321
HTR1B0.2515751
IFNA2--5752
UBC--5781
SOST--5795
IL2--5825
TMPRSS6--15849
CYLD--15851
RARA0.2516024
TNFSF4--6034
TWIST1--16128
HSF1--6191
OSR1--6192
DUSP10--6196
FOXP3--16270
GNAI2--6384
KRT1--16454
SRGN--6476
P2RX7--6517
XCL1--6562
MYLIP--6753
PLN0.2517018
PLAU--7091
ATG12--7101
ARG2--7159
LRPAP1--7280
TLR4--17283
ABCG8--7325
GIMAP5--7409
HCRT0.2517434
APLN--7473
ABHD6--7605
ARRB2--7639
TBK1--7642
NOG--17650
IL13--7741
IL10--17883
RAI1--7890
TSPAN8--8187
PIN1--8222
PCSK9--8260
IL12A--8331
MC1R--18333
AKAP1--8358
IFNL1--8380
AHSG--8418
CNR20.2518581
IL23R--18693
THBD--8900
JAK3--9292
ANXA2--9301
GHRL0.2519333
VTN--9385
FRZB--9553
EDN1--9566
INHBA--9731
ASPN--10001
ATG5--10016
OXT0.25110022
MGLL--10038
F2--110327
GSTP10.25110429
CAV3--110580
ADM--10761
ITCH--10863
SCGB1A1--10925
IL33--11000
SMTNL1--11045
ADAM17--11074
TRAF3--11127
APOH--11155
ADORA2B--11164
PMCH--11242
IL23A--11260
PCBP2--11316
ABCG5--11513
TIGIT--11516
AVP--111615
RNF125--11624
APOC2--11692
SERPINB2--11736
UTS2R--11874
APOA1--111900
CMKLR1--11967
PROC--12183
KLKB1--12237
TLR9--12436
PDGFB--12484
SERPINF2--12582
NOS3--12710
APOA2--12739
POMC0.25112902
ANXA5--12967
TNFRSF11B--13020
VSIG4--13286
LRRK2--113335
GATA6--113349
LEP0.25113368
NLRC5--13492
TNNT1--13517
PLAT--13559
CD24--113608
BPI--13701
IRAK3--14013
NDRG2--14228
BBS2--114317
TWIST2--14594
IL20RB--14711
TGFB10.25114736
F2RL1--15088
OTUD5--15267
LBP--15270
HERC5--15583
TNFRSF1A--16905
NLRP12--16984
CD380.25117453
F12--118401
ISG15--18915
ARRB1--19005
INS--119021
APOC3--19472
TNF0.25119823
SLC11A1--19965
EIF2AK3--20407
HDAC7--20410
HMOX1--20520
P2RX4--20526
SERPINE10.25120720
IDO1--20843
KCNQ4--120957
TRIM25--20977
KLF2--21209
ATP2A1--121263
CHRFAM7A--21295
APOE0.25121310
APOC1--21328
AXL--21695
IL6R--21793
THBS1--21993
KLK8--22103
TAX1BP1--22114
GP1BA--122153
UBB--22223
GRID2IP--22273
DDX58--22541
NOD2--122677
ADRB20.25122718
UBE2L6--22773
RPS27A--22920
ANXA2P2--23114
INPP5D--23241
NCKAP1L--23440
ECM1--123510
ANPEP--23922
P2RY2--24073
UBA52--24116
ADA0.5124175
RNF135--24280
IKBKE--24341
GBA--124709
IFIH1--24753
ACP5--24802
NR1H3--24805
UBA7--24901
GLRX3--24919
MAVS--25347
FXN--125366
NLRX1--25461
ANXA4--25807

Network

GO:0051241

Network
Enrichment
NameDescriptionExternal IDs
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HPRD: 01638  Ensembl: ENSG00000102468  HGNC: 5293 
ADNPactivity-dependent neuroprotector homeobox Entrez:23394  Ensembl: ENSG00000101126  HPRD: 09793  HGNC: 15766 
GRIK2glutamate receptor, ionotropic, kainate 2 Entrez:2898  Ensembl: ENSG00000164418  HGNC: 4580  HPRD: 00692 
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
GRIK1glutamate receptor, ionotropic, kainate 1 Entrez:2897  HGNC: 4579  HPRD: 00693  Ensembl: ENSG00000171189 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ADNPactivity-dependent neuroprotector homeobox
GRIK2glutamate receptor, ionotropic, kainate 2
SFRP1secreted frizzled-related protein 1
GRIK1glutamate receptor, ionotropic, kainate 1
Query geneGeneGene descriptionEdge score
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ADNPADNPactivity-dependent neuroprotector homeobox
GRIK2GRIK2glutamate receptor, ionotropic, kainate 2
SFRP1SFRP1secreted frizzled-related protein 1
GRIK1GRIK1glutamate receptor, ionotropic, kainate 1

Troyanskaya Laboratory - Princeton University