ASD

GO:0043410 positive regulation of MAPKKK cascade (127)

GeneInput weightStandardRank
PLCB1--161
SOX2--1125
PRKCE--156
FGFR2--1165
GRM50.251196
FGF9--241
MAPK8IP2--275
FBXW7--525
TGFB2--625
IGF1R--631
ADRA1A--937
MIF0.251948
CDC42--1083
DCC--1193
AR0.2511499
SPRY2--1552
SEMA4C--1644
FGFR3--11648
MAP3K10--1767
ADRB3--11787
GAB1--1864
ESR10.2511914
DRD20.2512071
HIPK2--2306
TAOK20.2512490
MID1--2525
WWC1--2640
FZD7--2714
WNT5A--2870
ILK--2917
NOX4--2930
FGF23--12939
LPAR1--2975
BMPER--3267
EDNRA--13271
FGF20--3325
ANGPT1--3376
CDON--3482
TEK--3541
KL--3641
WNT16--3772
AGT--13783
PELI2--4270
GCG--4286
FGF10--14373
ITGB1--4390
TAOK3--4471
IL1A--4552
IL6--14578
EDA2R--4611
TNFRSF11A--14672
PDGFA--4678
FGF18--4736
FGF4--4827
CD44--5047
DUSP19--5073
BMP4--15180
FGF21--5449
TAOK1--5452
GRM4--5804
GADD45B--6021
IL1B--16220
CTNNB10.2516229
WNT7A--6375
IL11--7322
GPR55--7357
TNFSF11--17511
ARRB2--7639
WNT7B--7693
TRAF4--7752
GPER1--7922
SEMA7A--9127
FGF2--9627
TAB1--9783
IL26--10272
FGF19--10321
LPAR3--10488
AXIN1--110905
INSR--110986
SDCBP--11081
GADD45G--11613
CCL19--11890
TLR9--12436
PDGFB--12484
F2R--12498
ARHGAP8--12529
BRAF--112672
RYK--12768
HRAS0.25112845
LEP0.25113368
RIPK2--13928
NENF--13932
SORBS3--14540
LPAR2--14606
F2RL1--15088
LAMTOR1--16694
MYD88--17730
ARRB1--19005
INS--119021
CCL21--19130
TNF0.25119823
OSM--19901
VEGFB--20069
TPD52L1--20081
TLR3--20315
S100A7--20886
LIF--20888
MAP4K2--20924
PDGFRB--21054
TRAF7--21105
CCR7--21314
ERBB2--121638
ST5--21696
TIRAP--21732
IL6R--21793
CARD9--122070
MAP4K1--22293
CD74--22633
NOD2--122677
ADRB20.25122718
CD36--22749
CD27--22987
MAP3K11--23341
IGF20.25123391
NOD1--23711
GAS6--25087
DUSP22--25132

Network

GO:0043410

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
SOX2SRY (sex determining region Y)-box 2 Entrez:6657  HGNC: 11195  HPRD: 08921  Ensembl: ENSG00000181449 
PRKCEprotein kinase C, epsilon Entrez:5581  HPRD: 01500  HGNC: 9401  Ensembl: ENSG00000171132 
FGFR2fibroblast growth factor receptor 2 Entrez:2263  HPRD: 01492  Ensembl: ENSG00000066468  HGNC: 3689 
GRM5glutamate receptor, metabotropic 5 Entrez:2915  HGNC: 4597  Ensembl: ENSG00000168959 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
SOX2SRY (sex determining region Y)-box 2
PRKCEprotein kinase C, epsilon
FGFR2fibroblast growth factor receptor 2
GRM5glutamate receptor, metabotropic 5
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
SOX2SOX2SRY (sex determining region Y)-box 2
PRKCEPRKCEprotein kinase C, epsilon
FGFR2FGFR2fibroblast growth factor receptor 2
GRM5GRM5glutamate receptor, metabotropic 5

Troyanskaya Laboratory - Princeton University