ASD

GO:0007213 muscarinic acetylcholine receptor signaling pathway (12)

GeneInput weightStandardRank
GNB1--15
PLCB1--161
CDK5R1--406
CHRM3--1462
CHRM2--2223
CHRM50.2512290
CHRM4--4460
ADRBK1--4864
AGRN0.2515611
GNAI2--6384
CHRM1--6680
GNA15--20239

Network

GO:0007213

Network
Enrichment
NameDescriptionExternal IDs
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1 Entrez:2782  HGNC: 4396  HPRD: 00766  Ensembl: ENSG00000078369 
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35) Entrez:8851  Ensembl: ENSG00000176749  HGNC: 1775  HPRD: 04586 
CHRM3cholinergic receptor, muscarinic 3 Entrez:1131  HGNC: 1952  HPRD: 00329 
CHRM2cholinergic receptor, muscarinic 2 Entrez:1129  Ensembl: ENSG00000181072  HGNC: 1951  HPRD: 00328 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRM3cholinergic receptor, muscarinic 3
CHRM2cholinergic receptor, muscarinic 2
Query geneGeneGene descriptionEdge score
GNB1GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
CDK5R1CDK5R1cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRM3CHRM3cholinergic receptor, muscarinic 3
CHRM2CHRM2cholinergic receptor, muscarinic 2

Troyanskaya Laboratory - Princeton University