ASD

GO:0017156 calcium ion-dependent exocytosis (26)

GeneInput weightStandardRank
VAMP2--57
RIMS30.251173
RIMS2--273
GLRB--302
STX1A0.251449
RIMS1--622
RAPGEF40.251635
TRIM36--1726
GLRA1--2146
SYT6--2947
TNP2--3274
PKDREJ--3626
AKAP3--3957
ACR--4233
PLCD4--6526
SDF4--6949
SCIN--11105
ARHGAP17--12735
ZP4--12785
PCSK4--13185
STX2--13464
ROPN1B--13977
SYT8--13980
CRCP--14120
VAMP3--20209
VAMP7--20557

Network

GO:0017156

Network
Enrichment
NameDescriptionExternal IDs
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2) Entrez:6844  HGNC: 12643  HPRD: 01717  Ensembl: ENSG00000220205 
RIMS3regulating synaptic membrane exocytosis 3 Entrez:9783  HGNC: 21292  HPRD: 17976  Ensembl: ENSG00000117016 
RIMS2regulating synaptic membrane exocytosis 2 Entrez:9699  HGNC: 17283  HPRD: 09436 
GLRBglycine receptor, beta Entrez:2743  HGNC: 4329  Ensembl: ENSG00000109738  HPRD: 11751 
STX1Asyntaxin 1A (brain) Entrez:6804  Ensembl: ENSG00000106089  HGNC: 11433  HPRD: 01721 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2)
RIMS3regulating synaptic membrane exocytosis 3
RIMS2regulating synaptic membrane exocytosis 2
GLRBglycine receptor, beta
STX1Asyntaxin 1A (brain)
Query geneGeneGene descriptionEdge score
VAMP2VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2)
RIMS3RIMS3regulating synaptic membrane exocytosis 3
RIMS2RIMS2regulating synaptic membrane exocytosis 2
GLRBGLRBglycine receptor, beta
STX1ASTX1Asyntaxin 1A (brain)

Troyanskaya Laboratory - Princeton University