ASD

GO:0002792 negative regulation of peptide secretion (26)

GeneInput weightStandardRank
ABCC8--1161
SFRP1--204
PPP3CA--278
PDE8B--1323
IRS1--11052
CARTPT0.2511181
ADRA2A0.2511556
DRD20.2512071
GHSR0.2512085
INHBB--2840
PDE3B--3088
PFKL--3172
ACVR1C--4200
PDE4C--4298
SIRT4--4743
KCNJ11--16868
SYTL4--7445
KCNQ1--18097
GHRL0.2519333
REST--13067
LEP0.25113368
PSMD9--13761
FAM3D--15418
SREBF1--16874
CD74--22633
HADH--125281

Network

GO:0002792

Network
Enrichment
NameDescriptionExternal IDs
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Entrez:6833  Ensembl: ENSG00000006071  HPRD: 02741  HGNC: 59 
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
PPP3CAprotein phosphatase 3, catalytic subunit, alpha isozyme Entrez:5530  HGNC: 9314  HPRD: 00234  Ensembl: ENSG00000138814 
PDE8Bphosphodiesterase 8B Entrez:8622  HGNC: 8794  Ensembl: ENSG00000113231  HPRD: 04546 
IRS1insulin receptor substrate 1 Entrez:3667  HPRD: 00943  HGNC: 6125 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8
SFRP1secreted frizzled-related protein 1
PPP3CAprotein phosphatase 3, catalytic subunit, alpha isozyme
PDE8Bphosphodiesterase 8B
IRS1insulin receptor substrate 1
Query geneGeneGene descriptionEdge score
ABCC8ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 8
SFRP1SFRP1secreted frizzled-related protein 1
PPP3CAPPP3CAprotein phosphatase 3, catalytic subunit, alpha isozyme
PDE8BPDE8Bphosphodiesterase 8B
IRS1IRS1insulin receptor substrate 1

Troyanskaya Laboratory - Princeton University