ASD

GO:0051058 negative regulation of small GTPase mediated signal transduction (27)

GeneInput weightStandardRank
NF10.251333
SLIT2--582
DGKZ--725
ADRA1A--937
DLC1--1105
SPRY2--1552
TNFAIP1--2377
RASAL2--2472
STMN3--2549
CUL30.512576
RASAL1--3061
PPP2CB--3383
DAB2IP--3635
SYNGAP10.2513673
BCL6--3994
KCTD130.2514138
RASA1--4166
ARAP3--6203
NUP62--19343
TNK1--9452
SPRY1--10579
SCAI--12809
MFN2--113282
RASAL3--13407
RASA4--13696
RASA2--15169
RASA3--20776

Network

GO:0051058

Network
Enrichment
NameDescriptionExternal IDs
NF1neurofibromin 1 Entrez:4763  HGNC: 7765  HPRD: 01203  Ensembl: ENSG00000196712 
SLIT2slit homolog 2 (Drosophila) Entrez:9353  Ensembl: ENSG00000145147  HPRD: 04776  HGNC: 11086 
DGKZdiacylglycerol kinase, zeta Entrez:8525  HPRD: 03260  HGNC: 2857  Ensembl: ENSG00000149091 
ADRA1Aadrenoceptor alpha 1A Entrez:148  HGNC: 277  Ensembl: ENSG00000120907  HPRD: 00081 
DLC1deleted in liver cancer 1 Entrez:10395  HPRD: 05035  HGNC: 2897  Ensembl: ENSG00000164741 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
NF1neurofibromin 1
SLIT2slit homolog 2 (Drosophila)
DGKZdiacylglycerol kinase, zeta
ADRA1Aadrenoceptor alpha 1A
DLC1deleted in liver cancer 1
Query geneGeneGene descriptionEdge score
NF1NF1neurofibromin 1
SLIT2SLIT2slit homolog 2 (Drosophila)
DGKZDGKZdiacylglycerol kinase, zeta
ADRA1AADRA1Aadrenoceptor alpha 1A
DLC1DLC1deleted in liver cancer 1

Troyanskaya Laboratory - Princeton University