ASD

GO:0045879 negative regulation of smoothened signaling pathway (16)

GeneInput weightStandardRank
RUNX2--1209
SALL1--408
CHRD--697
PTCH1--11149
SALL3--1561
FGFR3--11648
HHIP--2403
SERPINE2--2896
GPC3--15153
GAS1--5960
WNT7B--7693
KIF7--17773
CD3E--8226
TULP3--8569
GLI3--19032
SUFU--19989

Network

GO:0045879

Network
Enrichment
NameDescriptionExternal IDs
RUNX2runt-related transcription factor 2 Entrez:860  Ensembl: ENSG00000124813  HGNC: 10472  HPRD: 02566 
SALL1sal-like 1 (Drosophila) Entrez:6299  HGNC: 10524  Ensembl: ENSG00000103449  HPRD: 03742 
CHRDchordin Entrez:8646  Ensembl: ENSG00000090539  HGNC: 1949  HPRD: 04592 
PTCH1patched 1 Entrez:5727  Ensembl: ENSG00000185920  HGNC: 9585  HPRD: 03200 
SALL3sal-like 3 (Drosophila) Entrez:27164  HGNC: 10527  HPRD: 05467 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
RUNX2runt-related transcription factor 2
SALL1sal-like 1 (Drosophila)
CHRDchordin
PTCH1patched 1
SALL3sal-like 3 (Drosophila)
Query geneGeneGene descriptionEdge score
RUNX2RUNX2runt-related transcription factor 2
SALL1SALL1sal-like 1 (Drosophila)
CHRDCHRDchordin
PTCH1PTCH1patched 1
SALL3SALL3sal-like 3 (Drosophila)

Troyanskaya Laboratory - Princeton University