ASD

GO:0035249 synaptic transmission, glutamatergic (16)

GeneInput weightStandardRank
GRIN1--167
CACNA1A--1231
SHC3--330
PARK20.251634
GRM80.2511152
UNC13A--1521
SLC1A4--2417
GRIN2D--2724
CDK50.2513113
GRID20.2513322
CNIH2--4683
NAPB--11425
UNC13B--12427
PLAT--13559
P2RX1--20551
ADRB20.25122718

Network

GO:0035249

Network
Enrichment
NameDescriptionExternal IDs
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1 Entrez:2902  HGNC: 4584  HPRD: 15926  Ensembl: ENSG00000176884 
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit Entrez:773  HPRD: 03004  HGNC: 1388  Ensembl: ENSG00000141837 
SHC3SHC (Src homology 2 domain containing) transforming protein 3 Entrez:53358  HPRD: 12005  HGNC: 18181 
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin) Entrez:5071  HPRD: 03967  HGNC: 8607  Ensembl: ENSG00000185345 
GRM8glutamate receptor, metabotropic 8 Entrez:2918  Ensembl: ENSG00000179603  HPRD: 03071  HGNC: 4600 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
SHC3SHC (Src homology 2 domain containing) transforming protein 3
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)
GRM8glutamate receptor, metabotropic 8
Query geneGeneGene descriptionEdge score
GRIN1GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1
CACNA1ACACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit
SHC3SHC3SHC (Src homology 2 domain containing) transforming protein 3
PARK2PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)
GRM8GRM8glutamate receptor, metabotropic 8

Troyanskaya Laboratory - Princeton University