ASD

GO:0010498 proteasomal protein catabolic process (160)

GeneInput weightStandardRank
PSMA1--42
PSMB3--79
PSMA4--95
PSMD14--120
PSMD8--144
PSMA5--219
PSMB1--318
PSMA3--373
PSMC4--380
PSMC6--405
FBXW7--525
SIAH1--550
PSMB7--554
PSMB4--562
TRIM9--571
RBX1--575
PSMD2--595
UBE2D3--661
PPP2R5C--681
PSMB6--696
TOPORS--1698
UBE2S--748
PSMA7--782
PSMC3--794
PSMC5--831
PSMD1--867
PSMD6--884
PSMC1--904
PSMD3--909
PSMD11--943
PSMC2--952
CUL1--972
PSMD13--994
RNF4--1036
PSMD4--1166
TBL1XR10.2511298
PSMA6--1492
PSME4--1576
BUB3--1593
FBXW11--1610
PSMA2--1693
CDC34--1858
PSMD10--2012
UBE2I--2101
PSMD12--2120
TNFAIP1--2377
PSMD7--2386
TBL1X0.2512388
BTRC--2430
CUL30.512576
UBE2B--2708
STUB1--3156
RNF103--3313
PPP2CB--3383
PCNP--3576
YOD1--3620
TMEM67--13880
SEC61B--3964
FZR1--3987
VCP--4121
KCTD130.2514138
WWP1--4204
C2orf40--4658
SMURF1--4696
UBC--5781
RNF5--5935
SKP1--6164
UBE2E1--6513
FOXRED2--7059
KIAA0368--7099
DNAJB2--7177
PMAIP1--7387
PSME2--7488
ARRB2--7639
PSMB9--7654
PSMB2--7801
PSMA8--8114
FBXL3--8346
WFS10.2518575
ANAPC2--8902
CDC23--9012
NPLOC4--10031
KLHL20--10865
ANAPC10--11143
PCBP2--11316
PSME1--11612
WWP2--12103
RAD23A--12130
PSMB8--12378
HSPA5--13639
ANAPC11--13665
PSMD9--13761
BIRC2--13848
TRIM13--13984
PSMB11--14440
PSMB10--14502
FBXL15--14570
CRBN--14635
OS9--14884
CDC27--14913
FBXO2--14958
RNF187--15734
FBXO45--15844
NHLRC1--115939
PSME3--17451
DDB1--17563
DERL2--18090
PSMD5--18391
ARRB1--19005
FBXO4--19716
AMFR--19835
DERL3--20240
CDC26--21067
ERCC8--121190
FBXL5--21282
KCTD10--21446
EDEM1--21506
FBXO31--22074
UBB--22223
SYVN1--22468
UBXN1--22532
DERL1--22535
USP19--22742
MAD2L1--22813
RPS27A--22920
PSMF1--22952
FBXO6--23116
RNF216--23131
RBCK1--23437
HECTD3--23497
UBE2D1--23789
DNAJB9--23975
ERLEC1--23982
CDK1--24001
CDK2--24011
UBA52--24116
FAF1--24152
PTTG1--24185
EDEM3--24271
PSMB5--24489
JKAMP--24553
CCNB1--24648
AURKB--24711
HSP90B1--24821
ANAPC7--24876
CDC20--24914
ANAPC5--24931
ANAPC4--25215
ERLIN1--25275
UBE2C--25279
ERLIN2--25388
CDC16--25415
FBXO5--25430
SKP2--25453
CCNF--25521
ANAPC1--25548
PLK1--25689
BUB1B--125795
DNAJC10--25801
AURKA--125803

Network

GO:0010498

Network
Enrichment
NameDescriptionExternal IDs
PSMA1proteasome (prosome, macropain) subunit, alpha type, 1 Entrez:5682  Ensembl: ENSG00000129084  HPRD: 04170  HGNC: 9530 
PSMB3proteasome (prosome, macropain) subunit, beta type, 3 Entrez:5691  HPRD: 03709  Ensembl: ENSG00000108294  HGNC: 9540 
PSMA4proteasome (prosome, macropain) subunit, alpha type, 4 Entrez:5685  Ensembl: ENSG00000041357  HPRD: 10168  HGNC: 9533 
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Entrez:10213  HGNC: 16889  Ensembl: ENSG00000115233  HPRD: 06208 
PSMD8proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 Entrez:5714  Ensembl: ENSG00000099341  HPRD: 10171  HGNC: 9566 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PSMA1proteasome (prosome, macropain) subunit, alpha type, 1
PSMB3proteasome (prosome, macropain) subunit, beta type, 3
PSMA4proteasome (prosome, macropain) subunit, alpha type, 4
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD8proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
Query geneGeneGene descriptionEdge score
PSMA1PSMA1proteasome (prosome, macropain) subunit, alpha type, 1
PSMB3PSMB3proteasome (prosome, macropain) subunit, beta type, 3
PSMA4PSMA4proteasome (prosome, macropain) subunit, alpha type, 4
PSMD14PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD8PSMD8proteasome (prosome, macropain) 26S subunit, non-ATPase, 8

Troyanskaya Laboratory - Princeton University