ASD

GO:0043087 regulation of GTPase activity (191)

GeneInput weightStandardRank
GNAO1--3
PLCB1--161
RGS70.25180
RGS4--99
AMPH--118
SFRP1--204
PAFAH1B10.251208
ABR--211
RASGRF1--213
NF10.251333
RGS6--375
PTPRN20.251441
MAP2K10.251474
GNAQ--490
RGS11--567
JUN--647
DGKI--807
AGAP10.251833
RABGAP1--856
SIPA1L1--893
THY1--993
FGD1--11009
RAPGEF2--1064
DLC1--1105
ARHGAP5--1129
NDEL10.2511194
RAP1GAP--1195
RABGAP1L--1270
RGS17--1439
ELMOD1--1534
SPRY2--1552
GSK3B--1592
ARHGAP35--1706
TSC10.2511844
AGAP2--1884
DOCK40.2512053
CHN2--2211
PREX1--2219
RAP1GDS1--2274
RALGAPA1--2363
PREX2--2459
RASAL2--2472
STMN3--2549
RANGAP1--2553
ASAP2--2554
RGS5--2560
FZD10--2606
GIT1--2627
CDKL5--12680
RHOG--2753
DOCK1--2785
TBC1D10B--2796
BCR--12801
S1PR1--2910
RGS16--2915
RGS20--2998
RASAL1--3061
SOS1--13181
PTK2B--3191
SMAP1--3205
RGS12--3374
ARHGAP26--13447
DAB2IP--3635
SYNGAP10.2513673
RGS2--3677
ARHGAP1--3707
BCL6--3994
VAV3--4024
AGAP3--4033
RGS9--4146
RASA1--4166
MYO9B--4244
BIN1--4255
DYNLT1--4275
ARAP2--4306
ARFGAP1--4379
ARHGAP6--4472
WNT11--4528
RGS8--4592
ARHGAP29--4961
RGS22--5110
FOXJ1--5202
HTR2B--5233
ASAP1--5458
BVES--5536
AXIN2--15927
ALS2CR12--6098
ARAP3--6203
CXCL13--6358
ARL2--6405
RGS13--6632
GRHL3--6732
RALGAPA2--6758
TBCD--6876
RGS18--6917
BNIP2--6921
CCL11--7037
RASGRP3--7172
RGS1--7315
ERRFI1--7414
MLST8--7510
RAPGEF6--7525
SNX18--7859
PIN1--8222
TAX1BP3--8734
FGD3--9083
ACAP3--9115
SYDE1--9488
ADAP1--9576
RALBP1--10248
SYDE2--10285
SMAP2--10497
SPRY1--10579
AXIN1--110905
RGS14--11308
TSC20.25111448
FGD4--111677
CCL19--11890
TBC1D15--12177
ALS2--112325
RGS19--12486
AGAP11--12524
ARHGAP8--12529
ARHGEF19--12571
AGAP7--12689
RP2--112866
ARHGEF6--13050
LRRK2--113335
RASAL3--13407
FGD5--13516
RGS21--13538
SNX9--13625
RASA4--13696
ASAP3--14066
EPHA2--114150
ALDH1A1--14295
ARHGAP15--14909
RASA2--15169
MTOR--15435
FGD6--15723
AGAP4--15746
OPHN10.5116404
AGAP10--17449
AGFG1--17498
CCL24--17974
CTGLF11P--18607
FGD2--18783
ARRB1--19005
AGAP9--19043
CCL21--19130
CDC42EP2--19516
AGAP5--19774
AJUBA--19840
ARHGAP9--19961
CCL26--19975
GPR65--20238
IQGAP1--20290
ARHGEF16--20461
DOCK7--20528
AGFG2--20529
RASA3--20776
ARFGAP2--20834
AGAP6--21024
CCR7--21314
RAB3GAP2--21401
ADAP2--21582
ARHGAP4--21597
ELMOD2--21756
AGAP8--21764
FICD--21845
RGS3--21940
GMIP--22058
SIPA1--22102
RAB3GAP1--22229
ARHGEF10L--22238
ACAP2--22442
RGS10--22712
PTPLAD1--22865
GNB2L1--22873
VAV1--23026
SNX13--23361
NCKAP1L--23440
TBC1D2--23630
GIT2--23867
RACGAP1--24138
ARHGAP27--24221
RALGAPB--24333
SCRIB--24455
ACAP1--25394
ARFGAP3--25402
ARAP1--25493

Network

GO:0043087

Network
Enrichment
NameDescriptionExternal IDs
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Entrez:2775  HPRD: 00757  HGNC: 4389  Ensembl: ENSG00000087258 
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
RGS7regulator of G-protein signaling 7 Entrez:6000  HGNC: 10003  HPRD: 03948  Ensembl: ENSG00000182901 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
AMPHamphiphysin Entrez:273  HPRD: 02687  Ensembl: ENSG00000078053  HGNC: 471 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
RGS7regulator of G-protein signaling 7
RGS4regulator of G-protein signaling 4
AMPHamphiphysin
Query geneGeneGene descriptionEdge score
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
RGS7RGS7regulator of G-protein signaling 7
RGS4RGS4regulator of G-protein signaling 4
AMPHAMPHamphiphysin

Troyanskaya Laboratory - Princeton University