ASD

GO:0008277 regulation of G-protein coupled receptor protein signaling pathway (72)

GeneInput weightStandardRank
CAMK2B0.25111
PLCB1--161
RGS70.25180
RGS4--99
ADCYAP1--127
GRM50.251196
GNG4--277
RGS6--375
SNCA--1401
CNTN2--438
RGS11--567
USP33--922
PALM--1349
ADRA2A0.2511556
DRD20.2512071
GSK3A--2346
MGRN1--2411
TMOD2--2437
RGS5--2560
GIT1--2627
DRD30.2512757
RGS16--2915
RGS20--2998
GNG7--3138
PDE6H--3301
RGS12--3374
RGS2--3677
RGS9--4146
DYNLT1--4275
GRK4--4377
ITGB1--4390
GRK5--4585
RAMP3--4706
ADRBK1--4864
HTR2B--5233
HTR1B0.2515751
RIC8B--6188
USP20--6357
RGS13--6632
RGS18--6917
RPH3AL--7341
RASGRP4--7359
ABHD6--7605
ARRB2--7639
PLCE1--7692
RAMP2--7750
GPSM1--8846
RAMP1--9122
GIPR--9148
KLK6--9270
PTGDR2--9477
EDN1--9566
MGLL--10038
DTNBP1--11282
RGS14--11308
KLK14--12477
GRK1--112718
LRRK2--113335
KLK5--14798
GRK6--15852
ARRB1--19005
RPGRIP1L--19545
PDE6G--119831
ECE1--120668
RGS3--21940
PLEK--22429
ADRB20.25122718
PLD2--23098
CAV2--23834
GIT2--23867
ADA0.5124175
GTF2H2--25576

Network

GO:0008277

Network
Enrichment
NameDescriptionExternal IDs
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta Entrez:816  Ensembl: ENSG00000058404  HGNC: 1461  HPRD: 12127 
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
RGS7regulator of G-protein signaling 7 Entrez:6000  HGNC: 10003  HPRD: 03948  Ensembl: ENSG00000182901 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary) Entrez:116  HGNC: 241  HPRD: 02369  Ensembl: ENSG00000141433 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
RGS7regulator of G-protein signaling 7
RGS4regulator of G-protein signaling 4
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)
Query geneGeneGene descriptionEdge score
CAMK2BCAMK2Bcalcium/calmodulin-dependent protein kinase II beta
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
RGS7RGS7regulator of G-protein signaling 7
RGS4RGS4regulator of G-protein signaling 4
ADCYAP1ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)

Troyanskaya Laboratory - Princeton University