ASD

GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger (140)

GeneInput weightStandardRank
GNAO1--3
CNR10.25110
ADCY2--102
SSTR2--185
CRHR1--280
APLP1--335
HTR1E0.251415
NPY0.251456
CALCA--460
ADCY10.251466
DRD50.251482
GNAQ--490
ADORA1--498
PRKACB--544
NPY2R0.251597
GNAZ--618
FSHR--1648
DRD10.251662
OPRK10.251764
PTGER3--842
GNAL--860
ADRB1--866
GRIK30.251976
FLNA--1984
NPY1R0.2511012
HRH3--1240
PTHLH--11269
GNAI3--1340
AGTR20.2511418
HTR5A0.2511507
HTR70.2511529
ADRA2A0.2511556
GNAI1--1613
HTR1A0.2511672
SSTR1--1732
ADRB3--11787
ADCY8--1906
MC2R--1919
MCHR10.2512005
DRD20.2512071
HTR60.2512191
CHRM2--2223
CALCR--2247
CHRM50.2512290
GHRHR--2312
GNAS--12352
LHCGR0.2512362
ADCY9--2435
OPRM10.2512614
HTR1F--2699
FZD7--2714
DRD30.2512757
HTR4--2810
GNAT3--2884
RXFP1--2904
S1PR1--2910
SPECC1L--3048
TSHR--3078
PTH1R--3098
GNA11--3167
CALCRL0.2513258
OPRD10.2513266
MC4R0.2513280
MC5R--3358
GCGR--13430
GNA14--3434
CRHR2--3445
FZD3--3579
P2RY12--3680
ADRA1D--3761
AGT--13783
NPR3--3798
MTNR1B0.2513826
GNAT2--3923
MTNR1A0.2514011
GLP2R--4213
GCG--4286
ADCY5--4352
ADCY6--4362
GPR3--4384
CHRM4--4460
P2RY1--4483
AVPR1B0.2514502
AVPR2--14537
GHRH--4568
GRK5--4585
ADCY3--4618
CCR3--4859
XCR1--5374
PTH--5481
HTR1B0.2515751
GRM4--5804
GALR1--5954
ADRA1B0.2515964
GPR26--6001
MC3R0.2516322
RXFP2--16360
GNAI2--6384
S1PR3--6584
DRD40.2517058
HTR1D0.2517287
GLP1R--7291
RGS1--7315
OPRL10.2518293
MC1R--18333
ADCY4--8354
CNR20.2518581
SSTR50.2519084
GIPR--9148
HRH2--9388
PTGDR2--9477
ADORA2A0.2519605
UCN3--9836
VIPR10.25110225
PTGER4--10436
LPAR3--10488
SSTR4--10595
GNA12--10962
CORT--11364
INSL3--111614
SSTR3--12043
GNAT1--112585
GALR2--12784
CCR1--13007
FZD2--13981
FPR1--14197
CCL2--14604
ADM2--15430
PTGIR0.25117719
GPR78--19507
WASF2--19696
FZD6--19825
GNA15--20239
GNA13--20348
SLC9A3R1--21807
FZD1--22086
S1PR4--22365
ADRB20.25122718
TBL3--24403
ADCY7--25198

Network

GO:0007187

Network
Enrichment
NameDescriptionExternal IDs
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Entrez:2775  HPRD: 00757  HGNC: 4389  Ensembl: ENSG00000087258 
CNR1cannabinoid receptor 1 (brain) Entrez:1268  HGNC: 2159  Ensembl: ENSG00000118432  HPRD: 00259 
ADCY2adenylate cyclase 2 (brain) Entrez:108  HGNC: 233  HPRD: 00052  Ensembl: ENSG00000078295 
SSTR2somatostatin receptor 2 Entrez:6752  HPRD: 01674  HGNC: 11331 
CRHR1corticotropin releasing hormone receptor 1 Entrez:1394  Ensembl: ENSG00000120088  HGNC: 2357  HPRD: 08830 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
CNR1cannabinoid receptor 1 (brain)
ADCY2adenylate cyclase 2 (brain)
SSTR2somatostatin receptor 2
CRHR1corticotropin releasing hormone receptor 1
Query geneGeneGene descriptionEdge score
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
CNR1CNR1cannabinoid receptor 1 (brain)
ADCY2ADCY2adenylate cyclase 2 (brain)
SSTR2SSTR2somatostatin receptor 2
CRHR1CRHR1corticotropin releasing hormone receptor 1

Troyanskaya Laboratory - Princeton University