ASD

GO:0045860 positive regulation of protein kinase activity (312)

GeneInput weightStandardRank
PPP2CA--21
GAP43--29
YWHAB0.25145
HTR2A0.25151
ADNP0.5191
ADCY2--102
KRAS--1143
GRM50.251196
NRG10.251285
AKT10.251303
SNCA--1401
CDK5R1--406
RELN0.51436
CALCA--460
ADCY10.251466
MAP2K10.251474
ADORA1--498
MAP3K9--500
GRM10.251523
FBXW7--525
PRKACB--544
GNG3--591
TGFB2--625
CCND2--689
DGKZ--725
DGKI--807
PDCD10--883
MADD--898
CHRNA3--910
ERBB3--921
PRLR0.251955
PROX1--962
MAPK1--985
MAP2K20.2511066
DGKB--1122
PRKAR1B--1163
CARTPT0.2511181
MAP3K5--1245
MAPK11--1258
KIDINS220--1337
SPAG9--1398
PRKAR2B--1512
EDN3--11522
TNIK--1544
SPRY2--1552
ADRA2A0.2511556
TGFA--1563
SRCIN1--1623
CHRNA70.511657
DGKG--1661
CCK0.2511662
PRKAR1A--11718
MAP3K10--1767
CD81--11828
GAB1--1864
ADCY8--1906
PKN1--1964
PSMD10--2012
DRD20.2512071
MAP3K7--2169
ZFP91--2271
FLT10.2512278
ADCY9--2435
TAOK20.2512490
MAPK8IP3--2496
FZD10--2606
TAB2--2777
EGFR--12811
MAP3K13--2868
WNT5A--2870
ILK--2917
NOX4--2930
LPAR1--2975
SPECC1L--3048
CDK50.2513113
ACVR2B--13179
PTK2B--3191
CSF1--3235
EDNRA--13271
PDE6H--3301
SOD1--13330
PRKACG--3335
ANGPT1--3376
MAPKAPK2--3441
JTB--3557
MET1.013618
DAB2IP--3635
PROK2--13667
MAPKBP1--3672
NGF0.2513749
AGT--13783
CXCR4--4014
PDPK1--4150
HGF0.2514189
GCG--4286
ADCY5--4352
ADCY6--4362
FGF10--14373
DVL3--4438
PLA2G1B--4440
ITGB30.514442
CRK--4478
GH1--4570
ZEB2--4607
ADCY3--4618
TNFRSF11A--14672
PDGFA--4678
VEGFA0.2514691
MAPK14--4729
ADIPOQ0.2514834
WNT3A--4844
NTRK10.2514883
MAP4K5--4887
DGKE--4906
DUSP19--5073
CDC25B--5075
BMP4--15180
HTR2B--5233
CCND1--15288
TGFB3--15321
PARD3--5406
NRAS--15506
PAK2--5515
PAK1--5556
RAF10.2515559
HTR1B0.2515751
CCDC88A--5761
UBC--5781
GRM4--5804
IL2--5825
SHC1--5839
AXIN2--15927
STK4--6010
GADD45B--6021
TGFBR1--16027
MAPK30.2516096
TNFSF15--6158
DGKD--6199
IL1B--16220
WNT7A--6375
GNAI2--6384
TAB3--6412
ADRA2C--6524
MAP3K4--6590
CHRM1--6680
CERK--6698
PRKAG2--16710
MAP3K1--16751
TDGF1--6833
SPHK2--6952
DRD40.2517058
TLR4--17283
C1QTNF2--7354
HCRT0.2517434
PLCE1--7692
WNT7B--7693
RAP1A--7718
TRAF4--7752
TLR6--7973
KISS1R--8159
ADRA2B--8196
PROK1--8256
DDR2--8276
PIM1--8325
ADCY4--8354
MAP2K7--8382
ERN1--8410
EREG--8504
STRADA--8555
PDGFC--8686
PRKACA--8797
EGF0.2518839
PRDX2--8945
MAP2K3--9005
AFAP1L2--9020
CD4--9113
IRAK1--9309
GHRL0.2519333
PRKD3--9479
EDN1--9566
ADORA2A0.2519605
RAPGEF1--9624
FGF2--9627
DAXX--9639
TGFBR2--19756
TAB1--9783
DGKH--9885
MAP3K2--10013
GHR--110058
PIK3CB--10067
MAP2K6--10398
LPAR3--10488
MS4A2--10551
DLG1--10557
CERKL--110893
AXIN1--110905
INSR--110986
ADAM17--11074
ADORA2B--11164
IRAK2--11461
EPGN--11496
PICK1--11571
GADD45G--11613
FGD4--111677
ELANE--111717
MDFI--11799
LAMTOR2--11829
CCL19--11890
BDKRB1--11977
CCND3--12093
BIRC7--12220
RPTOR--12241
DVL2--12293
EPO--12314
ALS2--112325
TLR9--12436
PDGFB--12484
F2R--12498
FRS2--12610
BRAF--112672
DGKQ--12728
ZP4--12785
HRAS0.25112845
TNFRSF10B--12951
LRRK2--113335
EDN2--13347
CD24--113608
HSPA5--13639
CARD14--13915
RIPK2--13928
ITGA1--13957
IQGAP3--14020
AZU1--14133
FPR1--14197
DBNL--14433
LPAR2--14606
MDFIC--14627
CCNY--14714
TGFB10.25114736
MALT1--14761
TRAF6--14847
PTPRC--15053
HSPA2--15307
C5--115436
ZP3--15811
TP73--15964
C5AR1--16349
DGKK--16510
PILRB--17723
S1PR2--18246
INS--119021
AGK--19080
CCL21--19130
CYR61--19764
TNF0.25119823
PDE6G--119831
AJUBA--19840
SLC11A1--19965
JAK2--120033
TPD52L1--20081
PSEN1--20241
TLR3--20315
ADAM8--20729
MAP4K2--20924
PDGFRB--21054
TRAF7--21105
CCR7--21314
PRKAR2A--21408
SPHK1--21548
DOK7--21561
TNFRSF10A--21606
STRADB--21620
ERBB2--121638
EFNA1--21813
THBS1--21993
UBB--22223
SLC27A1--22268
MAP4K1--22293
SDC4--22313
CLSPN--22424
MUL1--22450
STK3--22605
CD74--22633
NOD2--122677
CARD10--22698
ADRB20.25122718
PTPLAD1--22865
LRP1--22904
RPS27A--22920
RIPK1--23173
MAP3K11--23341
AVPI1--23367
ACSL1--23377
IGF20.25123391
DGKA--23509
TRAF2--23633
MAPKAPK3--23643
NOD1--23711
SYK--23795
IKBKG--123817
PRKAG1--23828
CDK1--24001
UBA52--24116
ANG--124265
PRKAA1--24385
MAP3K6--24401
ADAM9--124801
IL1RN0.25124819
PPAP2A--25039
ADCY7--25198
TPX2--25619
CENPE--25769

Network

GO:0045860

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
GAP43growth associated protein 43 Entrez:2596  Ensembl: ENSG00000172020  HPRD: 01198  HGNC: 4140 
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HPRD: 01638  Ensembl: ENSG00000102468  HGNC: 5293 
ADNPactivity-dependent neuroprotector homeobox Entrez:23394  Ensembl: ENSG00000101126  HPRD: 09793  HGNC: 15766 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
GAP43growth associated protein 43
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ADNPactivity-dependent neuroprotector homeobox
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
GAP43GAP43growth associated protein 43
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
ADNPADNPactivity-dependent neuroprotector homeobox

Troyanskaya Laboratory - Princeton University