ASD

GO:0051047 positive regulation of secretion (175)

GeneInput weightStandardRank
SNAP250.2516
PLCB1--161
SOX11--66
CADPS--119
PRKCE--156
SLC6A10.251238
CRHR1--280
CRH--328
GABBR10.251352
NNAT--382
SNCA--1401
STX1A0.251449
CADM10.251452
NR3C1--463
ADORA1--498
PEX5L--531
CCKBR--533
TAC10.251543
SOX4--581
GRIN2B1.01599
PCSK1--604
TGFB2--625
ADRB1--866
MIF0.251948
CREB1--991
IRS1--11052
CARTPT0.2511181
EP300--11256
ACHE--1266
ISL1--1441
EDN3--11522
IRS2--11607
BAD--1647
ACVR2A--1768
RTN4--1776
SCAMP50.2511910
DRD20.2512071
RBP4--2097
DPYSL2--2131
GLRA1--2146
TRH--2296
GHRHR--2312
NCS1--2387
SLC18A1--2477
GLUD1--12592
INHBB--2840
WNT5A--2870
GCK--12874
SPECC1L--3048
CDK50.2513113
AVPR1A0.513141
NKX6-1--3174
GATA3--3207
INHA--3229
MGEA5--3440
AGT--13783
GAB2--3859
OXCT1--3898
CACNA1H1.013918
GIP--3965
NLRP30.2514091
GCG--4286
IRF3--4434
PLA2G1B--4440
GDNF--14462
P2RY1--4483
OXTR0.514494
AVPR1B0.2514502
IL1A--4552
GHRH--4568
IL6--14578
TNFRSF11A--14672
ADRBK1--4864
KNG1--5045
VEGFC--5203
HTR2B--5233
IFNG--15255
TGFB3--15321
PFKFB2--5518
TCF7L2--15670
SLC30A8--15810
IL2--5825
STXBP5--5936
NPPB--5967
TNFSF4--6034
TNFSF15--6158
IL1B--16220
P2RX7--6517
NR1H2--6604
LACRT--6955
CHIA--7055
IL5--7116
CAPN10--7136
CXCL12--7204
GLP1R--7291
RPH3AL--7341
APLN--7473
TNFSF11--17511
CCKAR--7616
TACR1--7688
IL13--7741
IL10--17883
RAB8B--8016
KISS1R--8159
PYDC1--8236
TRPV10.2518765
BLK--18856
PINK1--18983
AACS--9069
GIPR--9148
DOC2B--9220
GHRL0.2519333
EDN1--9566
ADORA2A0.2519605
INHBA--9731
UCN3--9836
OXT0.25110022
IL26--10272
MS4A2--10551
FFAR1--10658
IL33--11000
SCIN--11105
ADORA2B--11164
AVP--111615
CCL19--11890
PANX1--11963
HCAR2--12026
CRTAM--12092
F2R--12498
ZP4--12785
SERP1--13167
CLEC6A--13189
EDN2--13347
LEP0.25113368
TAC4--13539
PSMD9--13761
PLA2G10--14358
NR0B2--114446
PRKCQ--14566
CLEC9A--14681
TGFB10.25114736
F2RL1--15088
C5--115436
IL4R--15546
ZP3--15811
PYCARD--16138
NMU--16499
NLRP12--16984
CD380.25117453
FCER1G--17885
INS--119021
CD14--19755
TNF0.25119823
CHRNB20.25120277
P2RX4--20526
ADAM8--20729
LIF--20888
TNFRSF4--20950
AQP1--21019
NLRP2--21084
TRIM16--21315
GLMN--21507
SAA1--21772
NLRP1--22465
NOD2--122677
UNC13D--122679
SAA2--22914
PLD2--23098
CARD8--23614
SYK--23795
P2RY2--24073
ANG--124265
NPR1--24360
KCNN4--24686
ADAM9--124801

Network

GO:0051047

Network
Enrichment
NameDescriptionExternal IDs
SNAP25synaptosomal-associated protein, 25kDa Entrez:6616  Ensembl: ENSG00000132639  HPRD: 02637  HGNC: 11132 
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
SOX11SRY (sex determining region Y)-box 11 Entrez:6664  HGNC: 11191  Ensembl: ENSG00000176887  HPRD: 02940 
CADPSCa++-dependent secretion activator Entrez:8618  Ensembl: ENSG00000163618  HGNC: 1426  HPRD: 05236 
PRKCEprotein kinase C, epsilon Entrez:5581  HPRD: 01500  HGNC: 9401  Ensembl: ENSG00000171132 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SNAP25synaptosomal-associated protein, 25kDa
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
SOX11SRY (sex determining region Y)-box 11
CADPSCa++-dependent secretion activator
PRKCEprotein kinase C, epsilon
Query geneGeneGene descriptionEdge score
SNAP25SNAP25synaptosomal-associated protein, 25kDa
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
SOX11SOX11SRY (sex determining region Y)-box 11
CADPSCADPSCa++-dependent secretion activator
PRKCEPRKCEprotein kinase C, epsilon

Troyanskaya Laboratory - Princeton University