ASD

GO:0048011 nerve growth factor receptor signaling pathway (218)

GeneInput weightStandardRank
NTRK20.25128
YWHAB0.25145
KALRN--63
ARHGDIA--76
ADCY2--102
AP2S1--110
ADCYAP1--127
KRAS--1143
PRKCE--156
CALM3--195
ARHGEF4--203
ABR--211
RASGRF1--213
TRIO--246
MEF2C0.251248
SH3GL2--301
AKT10.251303
AP2M1--321
SHC3--330
TIAM1--369
RIT2--437
ARHGEF12--1444
ADCY10.251466
MAP2K10.251474
ARHGEF7--492
PHLPP1--505
OMG0.251521
PRKACB--544
PRKCA--613
ARHGEF9--1639
MCF2--650
CAMK4--673
RPS6KA5--677
CALM1--708
RPS6KA20.251711
PCSK6--731
YWHAE--772
ITPR1--1802
RPS6KA3--861
ARHGEF11--870
RHOA--973
MAPK1--985
CREB1--991
FGD1--11009
IRS1--11052
PIK3R10.2511065
MAP2K20.2511066
CDKN1B--1067
RICTOR--1074
MCF2L--1084
RAC1--1087
ADCYAP1R1--1132
PRKCI--1135
PRKAR1B--1163
PDE1C--1202
CLTA--1257
MAPK11--1258
PRKCG--11280
ELK1--1329
KIDINS220--1337
RELA--1352
HDAC2--1413
PRKAR2B--1512
GSK3B--1592
IRS2--11607
BAD--1647
ITSN1--1679
PDE1A--1704
PRKAR1A--11718
MAPK8--1764
RTN4--1776
PDE1B--1791
DUSP6--1889
ADCY8--1906
CLTC--1949
SHC2--2147
PREX1--2219
SRC--2241
PTEN1.012260
GSK3A--2346
CALM2--2360
ADCY9--2435
RASGRF2--2464
SOS2--2569
STAT3--12598
GRB2--2662
ARHGEF2--2743
TIAM2--2771
PIK3CA0.2512782
VAV2--2783
RALGDS--2833
FOXO3--2950
RALB--3082
NDN0.2513116
SOS1--13181
PRKACG--3335
AP2A2--3336
MAPKAPK2--3441
NGFR0.2513554
NGF0.2513749
MAG--3851
VAV3--4024
PDPK1--4150
DUSP4--4300
ARHGEF3--4334
ADCY5--4352
ADCY6--4362
ARHGEF17--4415
MAGED1--4429
CRK--4478
MAP2K5--4533
ADCY3--4618
CDKN1A--4620
MAPK7--4626
AKAP13--4708
MAPK14--4729
ADRBK1--4864
FURIN--4868
NTRK10.2514883
HDAC1--5284
AP2A1--5314
RALA--5445
BCL2L11--5454
PIK3R2--5501
NRAS--15506
RAF10.2515559
MDM2--5588
UBC--5781
PRKCD--5824
SHC1--5839
DUSP3--5845
AP2B1--5873
PLCG1--5952
MEF2A--6060
NFKBIA--6067
MAPK30.2516096
LINGO1--6233
RTN4R--6379
FOXO10.2516970
DUSP7--7411
MLST8--7510
RAP1A--7718
NET1--7744
NGEF--7891
CASP30.2517989
ADCY4--8354
ITPR2--8681
ARHGEF18--8718
PRKACA--8797
NGFRAP1--8980
FGD3--9083
IRAK1--9309
ADORA2A0.2519605
RAPGEF1--9624
PLEKHG2--10000
PIK3CB--10067
ZFYVE27--110161
FOXO4--10242
BCAR1--10308
ADAM17--11074
NR4A1--11126
TSC20.25111448
CHUK--11526
FGD4--111677
PCSK5--12160
RIT1--12169
PLEKHG5--12196
DNAL4--12597
FRS2--12610
BRAF--112672
APH1A--12706
AKT1S1--12840
HRAS0.25112845
CASP2--12965
ARHGEF6--13050
SORT1--13249
RIPK2--13928
PRDM4--14631
TRAF6--14847
MTOR--15435
ATF1--15773
TRIB3--16821
MYD88--17730
FGD2--18783
AATF--19262
HDAC3--19605
MAPK12--19748
NFKB1--20216
PSEN1--20241
MAPKAP1--20345
ARHGEF16--20461
ITGB3BP--21140
PRKAR2A--21408
PSEN2--21431
ARHGAP4--21597
OBSCN--21654
IKBKB--21674
PSENEN--121944
NCSTN--122027
RPS6KA1--22219
UBB--22223
ITPR3--22312
RPS6KB2--22371
CASP90.25122672
APH1B--22814
RPS27A--22920
VAV1--23026
SMPD2--23597
MAPK13--23617
MAPKAPK3--23643
UTP11L--23855
THEM4--23999
CDK1--24001
UBA52--24116
ARHGEF1--24198
SQSTM1--124354
ECT2--24948
ADCY7--25198

Network

GO:0048011

Network
Enrichment
NameDescriptionExternal IDs
NTRK2neurotrophic tyrosine kinase, receptor, type 2 Entrez:4915  Ensembl: ENSG00000148053  HPRD: 02712  HGNC: 8032 
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
KALRNkalirin, RhoGEF kinase Entrez:8997  HPRD: 06859  HGNC: 4814  Ensembl: ENSG00000160145 
ARHGDIARho GDP dissociation inhibitor (GDI) alpha Entrez:396  HGNC: 678  Ensembl: ENSG00000141522  HPRD: 03565 
ADCY2adenylate cyclase 2 (brain) Entrez:108  HGNC: 233  HPRD: 00052  Ensembl: ENSG00000078295 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
NTRK2neurotrophic tyrosine kinase, receptor, type 2
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
KALRNkalirin, RhoGEF kinase
ARHGDIARho GDP dissociation inhibitor (GDI) alpha
ADCY2adenylate cyclase 2 (brain)
Query geneGeneGene descriptionEdge score
NTRK2NTRK2neurotrophic tyrosine kinase, receptor, type 2
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
KALRNKALRNkalirin, RhoGEF kinase
ARHGDIAARHGDIARho GDP dissociation inhibitor (GDI) alpha
ADCY2ADCY2adenylate cyclase 2 (brain)

Troyanskaya Laboratory - Princeton University