ASD

GO:0007173 epidermal growth factor receptor signaling pathway (77)

GeneInput weightStandardRank
YWHAB0.25145
AP2S1--110
KRAS--1143
HGS--191
SH3GL2--301
AP2M1--321
SHC3--330
MAP2K10.251474
SOCS5--489
ARHGEF7--492
RPS6KA5--677
MAPK1--985
SOX9--11045
PIK3R10.2511065
MAP2K20.2511066
CDC42--1083
CLTA--1257
SPRY2--1552
TGFA--1563
GAB1--1864
CLTC--1949
ERBB2IP--2017
SRC--2241
CBL--2611
HBEGF--2652
GRB2--2662
PIK3CA0.2512782
EGFR--12811
ADAM12--2849
EPS15L1--3159
SOS1--13181
PTK2B--3191
AP2A2--3336
EPS15--3650
SH3KBP1--3651
REPS2--4368
NCK2--4595
CAMLG--5069
RAB7A--15208
PXN--5215
AP2A1--5314
NRAS--15506
RAF10.2515559
UBC--5781
SHC1--5839
AP2B1--5873
PLCG1--5952
MAPK30.2516096
DGKD--6199
STAM--6319
PAG1--6500
AREG--7185
PLCE1--7692
ARF4--7739
CSK--7954
EREG--8504
EGF0.2518839
PTPN11--110178
BCAR1--10308
SPRY1--10579
ADAM17--11074
HRAS0.25112845
TGFB10.25114736
AREGB--15659
EPN1--20958
ERBB2--121638
VIL1--22201
UBB--22223
KIF16B--22566
RPS27A--22920
GRB7--23181
EPS8--23694
ADAM10--23915
CDK1--24001
UBA52--24116
STAM2--24632
EFEMP1--24649

Network

GO:0007173

Network
Enrichment
NameDescriptionExternal IDs
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HGNC: 12849  Ensembl: ENSG00000166913  HPRD: 03184 
AP2S1adaptor-related protein complex 2, sigma 1 subunit Entrez:1175  HPRD: 03762  Ensembl: ENSG00000042753  HGNC: 565 
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  Ensembl: ENSG00000133703  HGNC: 6407  HPRD: 01817 
HGShepatocyte growth factor-regulated tyrosine kinase substrate Entrez:9146  Ensembl: ENSG00000185359  HPRD: 05085  HGNC: 4897 
SH3GL2SH3-domain GRB2-like 2 Entrez:6456  HGNC: 10831  Ensembl: ENSG00000107295  HPRD: 05125 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
AP2S1adaptor-related protein complex 2, sigma 1 subunit
KRASKirsten rat sarcoma viral oncogene homolog
HGShepatocyte growth factor-regulated tyrosine kinase substrate
SH3GL2SH3-domain GRB2-like 2
Query geneGeneGene descriptionEdge score
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
AP2S1AP2S1adaptor-related protein complex 2, sigma 1 subunit
KRASKRASKirsten rat sarcoma viral oncogene homolog
HGSHGShepatocyte growth factor-regulated tyrosine kinase substrate
SH3GL2SH3GL2SH3-domain GRB2-like 2

Troyanskaya Laboratory - Princeton University