ASD

GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway (107)

GeneInput weightStandardRank
ACVR1B--510
FKBP1A--605
TGFB2--625
JUN--647
UBE2D3--661
CHRD--697
USP9X--950
BMPR2--1964
BMP7--987
CREB1--991
NLK--1019
PTPRK--1053
ZFYVE9--1070
GDF10--1138
SMAD7--1283
MSX2--11405
SMAD3--1541
LEF1--1731
ACVR2A--1768
FOS--1839
CITED1--1867
GDF6--11929
LEFTY1--1970
CHRDL1--1977
BMPR1A--2059
SMAD6--2079
MAP3K7--2169
NODAL--12184
HIPK2--2306
MSX1--12365
BMPR1B--12397
GREM2--2556
T--2584
SMURF2--2642
SMAD1--2829
INHBB--2840
SMAD4--2927
STUB1--3156
ACVR2B--13179
BMP10--3196
BMP6--3242
WNT1--3263
KLF10--3421
EGR1--3527
BMP2--13686
MSTN--3712
AKAP3--3957
ZFYVE16--4127
SKI--4231
SMAD9--14245
GDF5--14557
PDGFA--4678
RGMB--4681
SMURF1--4696
FURIN--4868
AMHR2--4953
USP9Y--15087
BMP4--15180
CER1--5192
TGFB3--15321
GDF9--5351
LEFTY2--5386
AKAP4--5928
TGFBR1--16027
PPM1L--6683
MAP3K1--16751
SMAD2--7224
GDF7--7494
ARRB2--7639
NOG--17650
FST--8021
FSHB0.2518120
ID1--8270
SPTBN1--8272
AFP--8347
WFIKKN2--8494
TGFBRAP1--8700
TGFBR3--8717
IRAK1--9309
TGFBR2--19756
TAB1--9783
FSTL1--10151
GATA4--111137
SMAD5--11520
FOXH1--11747
ACVR1--111780
GDF2--11942
HNF4A--112281
PDGFB--12484
ACVRL1--114027
COL3A1--114131
TGFB10.25114736
GDF15--15127
ENG--117647
COL1A2--119210
HPGD--119722
POU5F1--21422
FNTA--21701
EID2--22443
FMOD--22528
TGFB1I1--22730
ECSIT--23466
UBE2D1--23789
ADAM9--124801
DUSP22--25132
PML--25248
LTBP2--125410

Network

GO:0007178

Network
Enrichment
NameDescriptionExternal IDs
ACVR1Bactivin A receptor, type IB Entrez:91  Ensembl: ENSG00000135503  HGNC: 172  HPRD: 03193 
FKBP1AFK506 binding protein 1A, 12kDa Entrez:2280  Ensembl: ENSG00000088832  HGNC: 3711  HPRD: 01741 
TGFB2transforming growth factor, beta 2 Entrez:7042  HGNC: 11768  Ensembl: ENSG00000092969  HPRD: 01828 
JUNjun proto-oncogene Entrez:3725  HGNC: 6204  HPRD: 01302  Ensembl: ENSG00000177606 
UBE2D3ubiquitin-conjugating enzyme E2D 3 Entrez:7323  Ensembl: ENSG00000109332  HPRD: 04269  HGNC: 12476 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
ACVR1Bactivin A receptor, type IB
FKBP1AFK506 binding protein 1A, 12kDa
TGFB2transforming growth factor, beta 2
JUNjun proto-oncogene
UBE2D3ubiquitin-conjugating enzyme E2D 3
Query geneGeneGene descriptionEdge score
ACVR1BACVR1Bactivin A receptor, type IB
FKBP1AFKBP1AFK506 binding protein 1A, 12kDa
TGFB2TGFB2transforming growth factor, beta 2
JUNJUNjun proto-oncogene
UBE2D3UBE2D3ubiquitin-conjugating enzyme E2D 3

Troyanskaya Laboratory - Princeton University