ASD

GO:0007200 activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger (54)

GeneInput weightStandardRank
GNB1--15
HTR2A0.25151
GRM50.251196
CRHR1--280
CALCA--460
DRD50.251482
GNAQ--490
NTSR2--493
CCKBR--533
DRD10.251662
PTGER3--842
ADRA1A--937
HCRTR20.2511101
EDNRB--11322
NMBR--1448
ADRA2A0.2511556
GNG13--1713
DRD20.2512071
CHRM2--2223
LHCGR0.2512362
AGTR1--12898
S1PR1--2910
LPAR1--2975
GNA11--3167
EDNRA--13271
GNA14--3434
AGT--13783
NPR3--3798
P2RY1--4483
RXFP3--5237
P2RY4--5261
HRH1--5298
NMUR2--5836
HOMER10.2516115
MC3R0.2516322
CHRM1--6680
HCRT0.2517434
F2RL3--7474
CCKAR--7616
TACR1--7688
PLCE1--7692
EDN1--9566
LPAR3--10488
CXCR2--11514
GPR139--11802
F2R--12498
NMUR1--13186
TGM2--13660
P2RY11--18359
GNA15--20239
LTB4R--21535
SLC9A3R1--21807
P2RY6--21915
P2RY2--24073

Network

GO:0007200

Network
Enrichment
NameDescriptionExternal IDs
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1 Entrez:2782  HGNC: 4396  HPRD: 00766  Ensembl: ENSG00000078369 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HPRD: 01638  Ensembl: ENSG00000102468  HGNC: 5293 
GRM5glutamate receptor, metabotropic 5 Entrez:2915  HGNC: 4597  Ensembl: ENSG00000168959 
CRHR1corticotropin releasing hormone receptor 1 Entrez:1394  Ensembl: ENSG00000120088  HGNC: 2357  HPRD: 08830 
CALCAcalcitonin-related polypeptide alpha Entrez:796  HGNC: 1437  HPRD: 00238  Ensembl: ENSG00000110680 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
GRM5glutamate receptor, metabotropic 5
CRHR1corticotropin releasing hormone receptor 1
CALCAcalcitonin-related polypeptide alpha
Query geneGeneGene descriptionEdge score
GNB1GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
GRM5GRM5glutamate receptor, metabotropic 5
CRHR1CRHR1corticotropin releasing hormone receptor 1
CALCACALCAcalcitonin-related polypeptide alpha

Troyanskaya Laboratory - Princeton University