ASD

GO:0042176 regulation of protein catabolic process (120)

GeneInput weightStandardRank
PPP2CA--21
GRIN2A0.25156
SUMO1--178
PSMD14--120
HGS--191
AKT10.251303
FBXW7--525
APC0.251528
TRIB2--534
PSMD2--595
NEDD4L--670
CSNK1D--811
PSMD1--867
RAD23B--868
PSMD3--909
FLNA--1984
WNT10B--1030
SOX9--11045
XPO1--1054
CDKN1B--1067
CDC42--1083
UBE2V2--1207
CSNK1E0.2511225
PRKCG--11280
SMAD7--1283
FYN--1284
RELA--1352
BAG6--1435
USP14--1445
SMAD3--1541
ADRA2A0.2511556
GSK3B--1592
RCHY1--1845
AGAP2--1884
PSMD10--2012
PTEN1.012260
TIMP1--2285
GSK3A--2346
BTRC--2430
HSP90AB1--2440
SUMO2--2503
WNT5A--2870
SERPINE2--2896
SMAD4--2927
STUB1--3156
WNT1--3263
TRIB1--3331
USP44--3386
CBLB--3413
SOX17--3484
N4BP1--3558
TNFAIP3--3628
RNF180--3828
ARNTL--3856
FZR1--3987
VCP--4121
BARD1--14151
NDFIP1--4331
FURIN--4868
PTPN3--5124
GPC3--15153
IFNG--15255
PRICKLE1--15311
TAF9--5472
MDM2--5588
SERPINB12--5630
GRIN2C--6011
IL1B--16220
HSPBP1--6359
GPX10.2516748
MYLIP--6753
NOS20.2517024
DNAJB2--7177
USP5--7638
SH3D19--7820
IL10--17883
GJA10.2518195
PCSK9--8260
MAPK15--9705
ITCH--10863
AXIN1--110905
MAD2L2--11317
RAD23A--12130
TRIM320.25112319
DYX1C10.25112369
LRRK2--113335
EGLN2--13499
GCLC--13506
IRAK3--14013
GIPC1--15140
SHH--115942
PSME3--17451
INS--119021
TNF0.25119823
PSEN1--20241
PACSIN3--20292
TAF1--20307
ADAM8--20729
TIMP3--20931
SNX1--21188
MDM4--21248
APOE0.25121310
NEDD40.25121604
COMMD1--22050
UBXN2A--22320
UBXN1--22532
MAD2L1--22813
GNB2L1--22873
SGSM3--22884
NUB1--23472
UCHL5--23734
NRD1--24048
FAF1--24152
FBXO22--24394
RHBDF1--24539
ADAM9--124801
DAB2--24837
CLU--24939
PML--25248
PLK1--25689

Network

GO:0042176

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A Entrez:2903  HGNC: 4585  Ensembl: ENSG00000183454  HPRD: 00698 
SUMO1small ubiquitin-like modifier 1 Entrez:7341  Ensembl: ENSG00000116030  HGNC: 12502  HPRD: 03554 
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Entrez:10213  HGNC: 16889  Ensembl: ENSG00000115233  HPRD: 06208 
HGShepatocyte growth factor-regulated tyrosine kinase substrate Entrez:9146  Ensembl: ENSG00000185359  HPRD: 05085  HGNC: 4897 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A
SUMO1small ubiquitin-like modifier 1
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
HGShepatocyte growth factor-regulated tyrosine kinase substrate
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
GRIN2AGRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A
SUMO1SUMO1small ubiquitin-like modifier 1
PSMD14PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
HGSHGShepatocyte growth factor-regulated tyrosine kinase substrate

Troyanskaya Laboratory - Princeton University