ASD

GO:0050806 positive regulation of synaptic transmission (35)

GeneInput weightStandardRank
NTRK20.25128
ERBB40.25164
GRIK20.51142
PRKCE--156
GRIK1--216
CRHR1--280
SNCA--1401
CCKBR--533
TAC10.251543
GRIN2B1.01599
LGI1--646
DRD10.251662
NR2E10.251699
GRIA4--1176
SLC24A2--1691
GFAP--11886
TNR--2784
SERPINE2--2896
SPECC1L--3048
PTGS20.2513176
NPTN--3227
GIP--3965
OXTR0.514494
SLC1A30.2515029
IFNG--15255
ARRB2--7639
TACR1--7688
KISS1R--8159
PINK1--18983
ADORA2A0.2519605
OXT0.25110022
RGS14--11308
NMU--16499
TNF0.25119823
CHRNB20.25120277

Network

GO:0050806

Network
Enrichment
NameDescriptionExternal IDs
NTRK2neurotrophic tyrosine kinase, receptor, type 2 Entrez:4915  Ensembl: ENSG00000148053  HPRD: 02712  HGNC: 8032 
ERBB4v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 Entrez:2066  HGNC: 3432  HPRD: 02767  Ensembl: ENSG00000178568 
GRIK2glutamate receptor, ionotropic, kainate 2 Entrez:2898  Ensembl: ENSG00000164418  HGNC: 4580  HPRD: 00692 
PRKCEprotein kinase C, epsilon Entrez:5581  HPRD: 01500  HGNC: 9401  Ensembl: ENSG00000171132 
GRIK1glutamate receptor, ionotropic, kainate 1 Entrez:2897  HGNC: 4579  HPRD: 00693  Ensembl: ENSG00000171189 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
NTRK2neurotrophic tyrosine kinase, receptor, type 2
ERBB4v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
GRIK2glutamate receptor, ionotropic, kainate 2
PRKCEprotein kinase C, epsilon
GRIK1glutamate receptor, ionotropic, kainate 1
Query geneGeneGene descriptionEdge score
NTRK2NTRK2neurotrophic tyrosine kinase, receptor, type 2
ERBB4ERBB4v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
GRIK2GRIK2glutamate receptor, ionotropic, kainate 2
PRKCEPRKCEprotein kinase C, epsilon
GRIK1GRIK1glutamate receptor, ionotropic, kainate 1

Troyanskaya Laboratory - Princeton University