ASD

GO:0070302 regulation of stress-activated protein kinase signaling cascade (113)

GeneInput weightStandardRank
PLCB1--161
GRIK20.51142
MAPK8IP2--275
AKT10.251303
MAPK8IP1--1326
MAP3K9--500
COPS5--623
TGFB2--625
MAP4K4--630
RAP2A--652
CDC42--1083
MAP3K5--1245
SPAG9--1398
SEMA4C--1644
MAP3K10--1767
NCOR1--1807
GAB1--1864
PKN1--1964
MAP3K7--2169
HIPK2--2306
TAOK20.2512490
MAPK8IP3--2496
MID1--2525
FZD10--2606
FZD7--2714
WNT5A--2870
AKT2--13025
PTK2B--3191
SFRP4--3511
DAB2IP--3635
WNT16--3772
CBS0.2514080
MECOM--4397
DVL3--4438
DIXDC1--4469
TAOK3--4471
IL1A--4552
ZEB2--4607
EDA2R--4611
TNFRSF11A--14672
MAP4K5--4887
PDCD4--4897
DUSP19--5073
LYN--5289
TAOK1--5452
PAK1--5556
DUSP3--5845
DUSP10--6196
IL1B--16220
WNT7A--6375
PPEF2--6387
MAP3K4--6590
MEN1--16723
MAP3K1--16751
FOXO10.2516970
WNT7B--7693
TRAF4--7752
TLR6--7973
MAP2K7--8382
EDN1--9566
DAXX--9639
MAP3K2--10013
IL26--10272
FGF19--10321
GSTP10.25110429
ITCH--10863
AXIN1--110905
SDCBP--11081
HIPK3--11588
FGD4--111677
MDFI--11799
CCL19--11890
BIRC7--12220
DVL2--12293
TLR9--12436
FKTN--112941
RIPK2--13928
DBNL--14433
MDFIC--14627
TRAF6--14847
AMBP--14902
ZNF675--15034
F2RL1--15088
TP73--15964
MYD88--17730
CCL21--19130
HDAC3--19605
TNF0.25119823
TPD52L1--20081
GPS2--20293
TLR3--20315
MAP4K2--20924
CCR7--21314
TIRAP--21732
CARD9--122070
MAP4K1--22293
MUL1--22450
NOD2--122677
PTPLAD1--22865
CD27--22987
SH3RF1--23055
RIPK1--23173
MAP3K11--23341
TRAF2--23633
NOD1--23711
SYK--23795
MAP3K6--24401
IL1RN0.25124819
NBR1--24836
AIDA--25079
FOXM1--25108
DUSP22--25132
IGBP1--25575

Network

GO:0070302

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
GRIK2glutamate receptor, ionotropic, kainate 2 Entrez:2898  Ensembl: ENSG00000164418  HGNC: 4580  HPRD: 00692 
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2 Entrez:23542  HPRD: 09674  Ensembl: ENSG00000008735  HGNC: 6883 
AKT1v-akt murine thymoma viral oncogene homolog 1 Entrez:207  HPRD: 01261  Ensembl: ENSG00000142208  HGNC: 391 
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1 Entrez:9479  HPRD: 05223  Ensembl: ENSG00000121653  HGNC: 6882 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GRIK2glutamate receptor, ionotropic, kainate 2
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2
AKT1v-akt murine thymoma viral oncogene homolog 1
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GRIK2GRIK2glutamate receptor, ionotropic, kainate 2
MAPK8IP2MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2
AKT1AKT1v-akt murine thymoma viral oncogene homolog 1
MAPK8IP1MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1

Troyanskaya Laboratory - Princeton University