ASD

GO:0045665 negative regulation of neuron differentiation (49)

GeneInput weightStandardRank
SOX2--1125
ASCL1--229
PAX60.251355
OLIG2--420
CNTN2--438
FOXG1--483
ZNF536--527
TTC3--627
NR2E10.251699
NKX2-2--771
BMP7--987
SOX9--11045
ID4--1171
PHOX2B--1326
ISL1--1441
ID2--1719
RTN4--1776
FOXA2--1835
APP--1991
CNTN41.012038
SOX3--2042
SOX21--2110
DLL1--2143
ZHX2--2748
MIB1--3110
SLC6A40.2513328
GDF11--3345
NOTCH1--13360
HOXA2--3750
HES5--4001
ITGB1--4390
DIXDC1--4469
SOX8--4770
DTX1--5135
LBX1--5371
LMX1A--5502
TLX3--5583
HES10.2515662
IRX3--8539
GLI3--19032
RHOC--9929
REST--13067
TP73--15964
NBN--121778
PRPF19--21797
CALR--22356
NOTCH3--22751
CTDSP1--23825
ASPM--125468

Network

GO:0045665

Network
Enrichment
NameDescriptionExternal IDs
SOX2SRY (sex determining region Y)-box 2 Entrez:6657  HGNC: 11195  HPRD: 08921  Ensembl: ENSG00000181449 
ASCL1achaete-scute complex homolog 1 (Drosophila) Entrez:429  HPRD: 00011  Ensembl: ENSG00000139352  HGNC: 738 
PAX6paired box 6 Entrez:5080  HPRD: 06167  Ensembl: ENSG00000007372  HGNC: 8620 
OLIG2oligodendrocyte lineage transcription factor 2 Entrez:10215  HPRD: 07334  Ensembl: ENSG00000205927  HGNC: 9398 
CNTN2contactin 2 (axonal) Entrez:6900  HGNC: 2172  Ensembl: ENSG00000184144  HPRD: 01826 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SOX2SRY (sex determining region Y)-box 2
ASCL1achaete-scute complex homolog 1 (Drosophila)
PAX6paired box 6
OLIG2oligodendrocyte lineage transcription factor 2
CNTN2contactin 2 (axonal)
Query geneGeneGene descriptionEdge score
SOX2SOX2SRY (sex determining region Y)-box 2
ASCL1ASCL1achaete-scute complex homolog 1 (Drosophila)
PAX6PAX6paired box 6
OLIG2OLIG2oligodendrocyte lineage transcription factor 2
CNTN2CNTN2contactin 2 (axonal)

Troyanskaya Laboratory - Princeton University