ASD

GO:0007271 synaptic transmission, cholinergic (19)

GeneInput weightStandardRank
CHRNA3--910
CHRNB3--1157
ACHE--1266
CHRNA40.2511580
CHRNA70.511657
BCHE--2123
SLC5A7--2681
SPECC1L--3048
CHRNB4--3723
COLQ--5538
CHRNE--8412
ADORA2A0.2519605
CHRNA10--9844
RAPSN--13568
CHRNB1--19654
CHRNB20.25120277
CHRFAM7A--21295
APOE0.25121310
NQO1--24933

Network

GO:0007271

Network
Enrichment
NameDescriptionExternal IDs
CHRNA3cholinergic receptor, nicotinic, alpha 3 (neuronal) Entrez:1136  HGNC: 1957  HPRD: 07511  Ensembl: ENSG00000080644 
CHRNB3cholinergic receptor, nicotinic, beta 3 (neuronal) Entrez:1142  HGNC: 1963  Ensembl: ENSG00000147432  HPRD: 00336 
ACHEacetylcholinesterase Entrez:43  HGNC: 108  Ensembl: ENSG00000087085  HPRD: 00010 
CHRNA4cholinergic receptor, nicotinic, alpha 4 (neuronal) Entrez:1137  HGNC: 1958  HPRD: 00333  Ensembl: ENSG00000101204 
CHRNA7cholinergic receptor, nicotinic, alpha 7 (neuronal) Entrez:1139  HPRD: 00339  HGNC: 1960 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CHRNA3cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB3cholinergic receptor, nicotinic, beta 3 (neuronal)
ACHEacetylcholinesterase
CHRNA4cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7cholinergic receptor, nicotinic, alpha 7 (neuronal)
Query geneGeneGene descriptionEdge score
CHRNA3CHRNA3cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNB3CHRNB3cholinergic receptor, nicotinic, beta 3 (neuronal)
ACHEACHEacetylcholinesterase
CHRNA4CHRNA4cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA7CHRNA7cholinergic receptor, nicotinic, alpha 7 (neuronal)

Troyanskaya Laboratory - Princeton University