ASD

GO:0045668 negative regulation of osteoblast differentiation (25)

GeneInput weightStandardRank
SFRP1--204
CHRD--697
HDAC4--963
SMAD3--1541
ID2--1719
CITED1--1867
CDK6--2224
FGFR1--2550
FGF23--12939
NOTCH1--13360
SKI--4231
AXIN2--15927
TWIST1--16128
MEN1--16723
NOG--17650
ID1--8270
UCMA--10818
OSTN--11307
TWIST2--14594
LRP5--116985
ID3--20004
HDAC7--20410
C14orf169--22418
NBR1--24836
TWSG1--25171

Network

GO:0045668

Network
Enrichment
NameDescriptionExternal IDs
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
CHRDchordin Entrez:8646  Ensembl: ENSG00000090539  HGNC: 1949  HPRD: 04592 
HDAC4histone deacetylase 4 Entrez:9759  Ensembl: ENSG00000068024  HPRD: 05610  HGNC: 14063 
SMAD3SMAD family member 3 Entrez:4088  HPRD: 04380  HGNC: 6769  Ensembl: ENSG00000166949 
ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix protein Entrez:3398  HPRD: 02664  HGNC: 5361  Ensembl: ENSG00000115738 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SFRP1secreted frizzled-related protein 1
CHRDchordin
HDAC4histone deacetylase 4
SMAD3SMAD family member 3
ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Query geneGeneGene descriptionEdge score
SFRP1SFRP1secreted frizzled-related protein 1
CHRDCHRDchordin
HDAC4HDAC4histone deacetylase 4
SMAD3SMAD3SMAD family member 3
ID2ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

Troyanskaya Laboratory - Princeton University