ASD

GO:0090090 negative regulation of canonical Wnt receptor signaling pathway (57)

GeneInput weightStandardRank
SOX2--1125
SFRP1--204
APC0.251528
APC2--671
SOX9--11045
LRP4--1290
HDAC2--1413
AES--1548
LEF1--1731
DKK2--2075
MCC--2843
WNT5A--2870
LATS1--3031
SOX17--3484
SFRP4--3511
EGR1--3527
DAB2IP--3635
SFRP2--3758
DKK3--4056
WNT11--4528
DRAXIN--4545
SIAH2--4934
GPC3--15153
PRICKLE1--15311
NKX2-50.2515490
TCF7L2--15670
SOST--5795
CYLD--15851
AXIN2--15927
STK4--6010
GLI1--6597
CTNND1--6834
DKK1--6892
TBX18--7034
TLE2--7919
GLI3--19032
FRZB--9553
SFRP5--9913
AXIN1--110905
MESP1--10948
WNT5B--11732
DDIT3--12944
NPHP3--114055
LATS2--15008
SHH--115942
FZD6--19825
WNT4--21840
FZD1--22086
INVS--122094
STK3--22605
WWTR1--22777
SNAI2--122934
PFDN5--23979
SCYL2--24230
CAV1--124767
CBY1--24830
DAB2--24837

Network

GO:0090090

Network
Enrichment
NameDescriptionExternal IDs
SOX2SRY (sex determining region Y)-box 2 Entrez:6657  HGNC: 11195  HPRD: 08921  Ensembl: ENSG00000181449 
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
APCadenomatous polyposis coli Entrez:324  HGNC: 583  HPRD: 01439  Ensembl: ENSG00000134982 
APC2adenomatosis polyposis coli 2 Entrez:10297  Ensembl: ENSG00000115266  HGNC: 24036  HPRD: 09802 
SOX9SRY (sex determining region Y)-box 9 Entrez:6662  HPRD: 06427  HGNC: 11204  Ensembl: ENSG00000125398 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SOX2SRY (sex determining region Y)-box 2
SFRP1secreted frizzled-related protein 1
APCadenomatous polyposis coli
APC2adenomatosis polyposis coli 2
SOX9SRY (sex determining region Y)-box 9
Query geneGeneGene descriptionEdge score
SOX2SOX2SRY (sex determining region Y)-box 2
SFRP1SFRP1secreted frizzled-related protein 1
APCAPCadenomatous polyposis coli
APC2APC2adenomatosis polyposis coli 2
SOX9SOX9SRY (sex determining region Y)-box 9

Troyanskaya Laboratory - Princeton University