ASD

GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway (26)

GeneInput weightStandardRank
CAMK2B0.25111
GRM50.251196
SNCA--1401
PALM--1349
ADRA2A0.2511556
DRD20.2512071
MGRN1--2411
DRD30.2512757
RGS12--3374
RGS2--3677
GRK4--4377
ADRBK1--4864
HTR2B--5233
HTR1B0.2515751
RGS13--6632
RPH3AL--7341
ARRB2--7639
GIPR--9148
KLK14--12477
ARRB1--19005
RPGRIP1L--19545
PLEK--22429
ADRB20.25122718
PLD2--23098
ADA0.5124175
GTF2H2--25576

Network

GO:0045744

Network
Enrichment
NameDescriptionExternal IDs
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta Entrez:816  Ensembl: ENSG00000058404  HGNC: 1461  HPRD: 12127 
GRM5glutamate receptor, metabotropic 5 Entrez:2915  HGNC: 4597  Ensembl: ENSG00000168959 
SNCAsynuclein, alpha (non A4 component of amyloid precursor) Entrez:6622  HPRD: 01227  HGNC: 11138  Ensembl: ENSG00000145335 
PALMparalemmin Entrez:5064  HGNC: 8594  Ensembl: ENSG00000099864  HPRD: 09734 
ADRA2Aadrenoceptor alpha 2A Entrez:150  HGNC: 281  HPRD: 00078  Ensembl: ENSG00000150594 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta
GRM5glutamate receptor, metabotropic 5
SNCAsynuclein, alpha (non A4 component of amyloid precursor)
PALMparalemmin
ADRA2Aadrenoceptor alpha 2A
Query geneGeneGene descriptionEdge score
CAMK2BCAMK2Bcalcium/calmodulin-dependent protein kinase II beta
GRM5GRM5glutamate receptor, metabotropic 5
SNCASNCAsynuclein, alpha (non A4 component of amyloid precursor)
PALMPALMparalemmin
ADRA2AADRA2Aadrenoceptor alpha 2A

Troyanskaya Laboratory - Princeton University