GO:0046627 negative regulation of insulin receptor signaling pathway (17)

GeneInput weightStandardRank
IRS1--11052
PRKCZ--1110
RELA--1352
GRB10--2023
GSK3A--2346
RPS6KB1--2773
PTPRE--2873
ENPP1--15674
PRKCD--5824
GRB14--5898
IL1B--16220
PTPRF--6764
PTPN1--17469
AHSG--8418
SOCS1--9996
INPPL1--11037
SOCS3--15768

Network

GO:0046627

Network
Enrichment
NameDescriptionExternal IDs
IRS1insulin receptor substrate 1 Entrez:3667  HPRD: 00943  HGNC: 6125 
PRKCZprotein kinase C, zeta Entrez:5590  Ensembl: ENSG00000067606  HPRD: 01504  HGNC: 9412 
RELAv-rel avian reticuloendotheliosis viral oncogene homolog A Entrez:5970  HGNC: 9955  HPRD: 01241  Ensembl: ENSG00000173039 
GRB10growth factor receptor-bound protein 10 Entrez:2887  Ensembl: ENSG00000106070  HGNC: 4564  HPRD: 03312 
GSK3Aglycogen synthase kinase 3 alpha Entrez:2931  HGNC: 4616  HPRD: 06002  Ensembl: ENSG00000105723 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
IRS1insulin receptor substrate 1
PRKCZprotein kinase C, zeta
RELAv-rel avian reticuloendotheliosis viral oncogene homolog A
GRB10growth factor receptor-bound protein 10
GSK3Aglycogen synthase kinase 3 alpha
Query geneGeneGene descriptionEdge score
IRS1IRS1insulin receptor substrate 1
PRKCZPRKCZprotein kinase C, zeta
RELARELAv-rel avian reticuloendotheliosis viral oncogene homolog A
GRB10GRB10growth factor receptor-bound protein 10
GSK3AGSK3Aglycogen synthase kinase 3 alpha