ASD

GO:0007219 Notch signaling pathway (55)

GeneInput weightStandardRank
SPEN--170
CNTN1--199
EFNB2--200
ASCL1--229
NRG10.251285
HOXD3--785
DLL3--1816
HEY1--1114
CNTN6--1424
DTX3--1639
DNER--1640
MAML1--1664
JAG2--1852
APP--1991
DLL1--2143
RBPJ--2433
JAG1--12588
DTX4--2916
NEUROD4--2990
MIB1--3110
BMP10--3196
NOTCH1--13360
HEY2--3529
FURIN--4868
DLL4--5152
HES10.2515662
MAML2--6497
HES7--16789
MAML3--7206
FOXC2--8308
NOTCH2--19863
RBM15--10015
HEYL--10561
ADAM17--11074
NOTCH4--12179
APH1A--12706
FOXS1--15328
DTX2--16354
SEL1L--19838
PSEN1--20241
MIB2--20611
POFUT1--20890
PSEN2--21431
PSENEN--121944
NCSTN--122027
NOTCH2NL--22559
NOTCH3--22751
APH1B--22814
FOXC1--122868
NKAP--23149
CFD--23288
MESP2--123558
ADAM10--23915
NLE1--24847
WDR12--25818

Network

GO:0007219

Network
Enrichment
NameDescriptionExternal IDs
SPENspen homolog, transcriptional regulator (Drosophila) Entrez:23013  HPRD: 10230  Ensembl: ENSG00000065526  HGNC: 17575 
CNTN1contactin 1 Entrez:1272  HGNC: 2171  HPRD: 07189  Ensembl: ENSG00000018236 
EFNB2ephrin-B2 Entrez:1948  Ensembl: ENSG00000125266  HPRD: 02754  HGNC: 3227 
ASCL1achaete-scute complex homolog 1 (Drosophila) Entrez:429  HPRD: 00011  Ensembl: ENSG00000139352  HGNC: 738 
NRG1neuregulin 1 Entrez:3084  HPRD: 00802  Ensembl: ENSG00000157168  HGNC: 7997 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SPENspen homolog, transcriptional regulator (Drosophila)
CNTN1contactin 1
EFNB2ephrin-B2
ASCL1achaete-scute complex homolog 1 (Drosophila)
NRG1neuregulin 1
Query geneGeneGene descriptionEdge score
SPENSPENspen homolog, transcriptional regulator (Drosophila)
CNTN1CNTN1contactin 1
EFNB2EFNB2ephrin-B2
ASCL1ASCL1achaete-scute complex homolog 1 (Drosophila)
NRG1NRG1neuregulin 1

Troyanskaya Laboratory - Princeton University