ASD

GO:0007215 glutamate signaling pathway (26)

GeneInput weightStandardRank
GRIA30.25152
GRIN2A0.25156
PLCB1--161
GRIK20.51142
GRIN1--167
GRM50.251196
GRIK1--216
CDK5R1--406
GNAQ--490
GRIN2B1.01599
ATP1A3--918
GRIK30.251976
GRIA4--1176
SSTR1--1732
HOMER3--1905
APP--1991
GRM6--12069
GRIN3A--2501
GRID20.2513322
GRIK4--5391
GRM4--5804
GRIN2C--6011
HOMER10.2516115
GRIN3B--9998
HOMER2--10879
CLN3--113525

Network

GO:0007215

Network
Enrichment
NameDescriptionExternal IDs
GRIA3glutamate receptor, ionotropic, AMPA 3 Entrez:2892  Ensembl: ENSG00000125675  HGNC: 4573  HPRD: 02378 
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A Entrez:2903  HGNC: 4585  Ensembl: ENSG00000183454  HPRD: 00698 
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
GRIK2glutamate receptor, ionotropic, kainate 2 Entrez:2898  Ensembl: ENSG00000164418  HGNC: 4580  HPRD: 00692 
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1 Entrez:2902  HGNC: 4584  HPRD: 15926  Ensembl: ENSG00000176884 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GRIA3glutamate receptor, ionotropic, AMPA 3
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GRIK2glutamate receptor, ionotropic, kainate 2
GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1
Query geneGeneGene descriptionEdge score
GRIA3GRIA3glutamate receptor, ionotropic, AMPA 3
GRIN2AGRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
GRIK2GRIK2glutamate receptor, ionotropic, kainate 2
GRIN1GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1

Troyanskaya Laboratory - Princeton University