ASD

GO:0070555 response to interleukin-1 (51)

GeneInput weightStandardRank
PLCB1--161
SFRP1--204
SNCA--1401
PCSK1--604
PRKCA--613
RPS6KA5--677
VLDLR0.251837
HDAC4--963
SOX9--11045
PRKCI--1135
RELA--1352
AES--1548
CITED1--1867
XYLT1--12006
SRC--2241
RBMX--2432
CYBA--13439
EGR1--3527
CYP11A10.2514559
TNFRSF11A--14672
FIGF--5086
ETS1--5230
TAF9--5472
SLC30A8--15810
MAPK30.2516096
ANXA1--7465
IRAK1--9309
MMP3--9321
EDN1--9566
GHR--110058
SELE--10573
IRAK2--11461
EPO--12314
MYLK3--12912
HNMT--13018
RPS6KA4--13250
RIPK2--13928
IRAK3--14013
CHI3L1--14050
ICAM1--14063
CCL2--14604
TRAF6--14847
CD380.25117453
MYD88--17730
IL1R1--21051
KLF2--21209
IRF1--121687
MMP9--23766
P2RY2--24073
LCN2--25216
IGBP1--25575

Network

GO:0070555

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
SNCAsynuclein, alpha (non A4 component of amyloid precursor) Entrez:6622  HPRD: 01227  HGNC: 11138  Ensembl: ENSG00000145335 
PCSK1proprotein convertase subtilisin/kexin type 1 Entrez:5122  HGNC: 8743  HPRD: 01201  Ensembl: ENSG00000175426 
PRKCAprotein kinase C, alpha Entrez:5578  HPRD: 01498  Ensembl: ENSG00000154229  HGNC: 9393 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
SFRP1secreted frizzled-related protein 1
SNCAsynuclein, alpha (non A4 component of amyloid precursor)
PCSK1proprotein convertase subtilisin/kexin type 1
PRKCAprotein kinase C, alpha
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
SFRP1SFRP1secreted frizzled-related protein 1
SNCASNCAsynuclein, alpha (non A4 component of amyloid precursor)
PCSK1PCSK1proprotein convertase subtilisin/kexin type 1
PRKCAPRKCAprotein kinase C, alpha

Troyanskaya Laboratory - Princeton University