ASD

GO:0030901 midbrain development (28)

GeneInput weightStandardRank
FGFR2--1165
LRP6--778
RFX4--924
EN20.2511204
OTX2--11295
MSX1--12365
FGFR1--2550
SMAD1--2829
WNT1--3263
FZD3--3579
EN1--3999
OTX1--4110
FOXB1--4202
SMAD9--14245
BARHL1--4409
HES10.2515662
NDST1--5799
GDF7--7494
JHDM1D--8559
KDM2B--8663
UQCRQ--8688
HES3--8916
TAL2--9456
PITX30.25112815
SHH--115942
FZD6--19825
KAT2A--22874
UCHL5--23734

Network

GO:0030901

Network
Enrichment
NameDescriptionExternal IDs
FGFR2fibroblast growth factor receptor 2 Entrez:2263  HPRD: 01492  Ensembl: ENSG00000066468  HGNC: 3689 
LRP6low density lipoprotein receptor-related protein 6 Entrez:4040  Ensembl: ENSG00000070018  HGNC: 6698  HPRD: 04617 
RFX4regulatory factor X, 4 (influences HLA class II expression) Entrez:5992  Ensembl: ENSG00000111783  HGNC: 9985  HPRD: 04905 
EN2engrailed homeobox 2 Entrez:2020  HGNC: 3343  HPRD: 08836  Ensembl: ENSG00000164778 
OTX2orthodenticle homeobox 2 Entrez:5015  HGNC: 8522  HPRD: 07190  Ensembl: ENSG00000165588 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
FGFR2fibroblast growth factor receptor 2
LRP6low density lipoprotein receptor-related protein 6
RFX4regulatory factor X, 4 (influences HLA class II expression)
EN2engrailed homeobox 2
OTX2orthodenticle homeobox 2
Query geneGeneGene descriptionEdge score
FGFR2FGFR2fibroblast growth factor receptor 2
LRP6LRP6low density lipoprotein receptor-related protein 6
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)
EN2EN2engrailed homeobox 2
OTX2OTX2orthodenticle homeobox 2

Troyanskaya Laboratory - Princeton University