ASD

GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process (46)

GeneInput weightStandardRank
SIAH1--550
HECW1--606
PARK20.251634
NEDD4L--670
UBE3A0.251917
HECTD2--1399
UBR5--1553
RCHY1--1845
FBXL14--2000
TRIP12--2013
HERC2--2083
RNF11--2304
RBBP6--2522
SMURF2--2642
UBE4B--2923
HECW2--3037
HERC4--3244
LNX1--3654
HECTD4--3687
WWP1--4204
SMURF1--4696
HUWE1--4890
MDM2--5588
HERC3--6658
MAP3K1--16751
MYLIP--6753
ARIH2--7215
UBE3C--7312
RNF217--8431
HACE1--9642
ITCH--10863
HECTD1--10955
WWP2--12103
TRIM320.25112319
AREL1--14034
HERC6--14810
OS9--14884
HERC5--15583
FBXO45--15844
DDB1--17563
RNF146--20728
CBLC--20918
UBE3B--21334
NEDD40.25121604
RNF144B--22105
HECTD3--23497

Network

GO:0042787

Network
Enrichment
NameDescriptionExternal IDs
SIAH1siah E3 ubiquitin protein ligase 1 Entrez:6477  Ensembl: ENSG00000196470  HGNC: 10857  HPRD: 03736 
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 Entrez:23072  HGNC: 22195  HPRD: 11385  Ensembl: ENSG00000002746 
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin) Entrez:5071  HPRD: 03967  HGNC: 8607  Ensembl: ENSG00000185345 
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Entrez:23327  HGNC: 7728  HPRD: 05903  Ensembl: ENSG00000049759 
UBE3Aubiquitin protein ligase E3A Entrez:7337  HPRD: 03375  HGNC: 12496  Ensembl: ENSG00000114062 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SIAH1siah E3 ubiquitin protein ligase 1
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
UBE3Aubiquitin protein ligase E3A
Query geneGeneGene descriptionEdge score
SIAH1SIAH1siah E3 ubiquitin protein ligase 1
HECW1HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
PARK2PARK2parkinson protein 2, E3 ubiquitin protein ligase (parkin)
NEDD4LNEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
UBE3AUBE3Aubiquitin protein ligase E3A

Troyanskaya Laboratory - Princeton University