ASD

GO:0000188 inactivation of MAPK activity (24)

GeneInput weightStandardRank
PPP2CA--21
RGS4--99
SPRED2--643
DUSP8--796
PPP2R1A--852
SPRED1--1282
DUSP5--1317
DUSP6--1889
GPS1--2030
DUSP1--2140
DUSP4--4300
DUSP3--5845
DUSP10--6196
DUSP7--7411
DUSP9--7653
DUSP2--7903
DUSP16--9952
MBIP--10795
LAX1--10896
SPRED3--19822
GPS2--20293
RGS3--21940
CAV1--124767
DUSP22--25132

Network

GO:0000188

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
SPRED2sprouty-related, EVH1 domain containing 2 Entrez:200734  Ensembl: ENSG00000198369  HGNC: 17722  HPRD: 18100 
DUSP8dual specificity phosphatase 8 Entrez:1850  Ensembl: ENSG00000184545  HGNC: 3074  HPRD: 03617 
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha Entrez:5518  HPRD: 16184  HGNC: 9302 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4regulator of G-protein signaling 4
SPRED2sprouty-related, EVH1 domain containing 2
DUSP8dual specificity phosphatase 8
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4RGS4regulator of G-protein signaling 4
SPRED2SPRED2sprouty-related, EVH1 domain containing 2
DUSP8DUSP8dual specificity phosphatase 8
PPP2R1APPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha

Troyanskaya Laboratory - Princeton University