GO:0048009 insulin-like growth factor receptor signaling pathway (13)

GeneInput weightStandardRank
PLCB1--161
AKT10.251303
IGF1R--631
IRS1--11052
PIK3R10.2511065
GRB10--2023
GIGYF2--14627
CRIM1--4964
GHR--110058
TSC20.25111448
IGF2R--13558
GIGYF1--14840
EIF2AK3--20407

Network

GO:0048009

Network
Enrichment
NameDescriptionExternal IDs
PLCB1phospholipase C, beta 1 (phosphoinositide-specific) Entrez:23236  HGNC: 15917  HPRD: 06177  Ensembl: ENSG00000182621 
AKT1v-akt murine thymoma viral oncogene homolog 1 Entrez:207  HPRD: 01261  Ensembl: ENSG00000142208  HGNC: 391 
IGF1Rinsulin-like growth factor 1 receptor Entrez:3480  Ensembl: ENSG00000140443  HPRD: 00932  HGNC: 5465 
IRS1insulin receptor substrate 1 Entrez:3667  HPRD: 00943  HGNC: 6125 
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Entrez:5295  HGNC: 8979  Ensembl: ENSG00000145675  HPRD: 01381 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
AKT1v-akt murine thymoma viral oncogene homolog 1
IGF1Rinsulin-like growth factor 1 receptor
IRS1insulin receptor substrate 1
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Query geneGeneGene descriptionEdge score
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)
AKT1AKT1v-akt murine thymoma viral oncogene homolog 1
IGF1RIGF1Rinsulin-like growth factor 1 receptor
IRS1IRS1insulin receptor substrate 1
PIK3R1PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)