ASD

GO:0071901 negative regulation of protein serine/threonine kinase activity (77)

GeneInput weightStandardRank
PPP2CA--21
RGS4--99
UCHL1--1317
MAPK8IP1--1326
NF10.251333
APC0.251528
SPRED2--643
LRP6--778
DUSP8--796
PPP2R1A--852
BMP7--987
CDKN1B--1067
SPRED1--1282
DUSP5--1317
SPRY2--1552
DUSP6--1889
GPS1--2030
HMGCR--2128
DUSP1--2140
PTEN1.012260
ABL1--2653
LATS1--3031
SPRY4--3540
DAB2IP--3635
RGS2--3677
DUSP4--4300
NR2F2--4609
CDKN1A--4620
ADIPOQ0.2514834
PDCD4--4897
DUSP19--5073
BMP4--15180
MYOCD--5769
PRKCD--5824
DUSP3--5845
DUSP10--6196
IL1B--16220
TFAP4--6483
MEN1--16723
PTPRJ--17218
DUSP7--7411
DUSP9--7653
DUSP2--7903
HEXIM1--8261
NUP62--19343
CDKN2A--19650
DUSP16--9952
GSTP10.25110429
SPRY1--10579
CAV3--110580
MBIP--10795
LAX1--10896
INPPL1--11037
RGS14--11308
TSC20.25111448
HIPK3--11588
IRAK3--14013
LATS2--15008
ZNF675--15034
STK380.25115423
TP73--15964
LRP5--116985
SPRED3--19822
GPS2--20293
KAT2B--20429
HEXIM2--20619
CBLC--20918
APOE0.25121310
RGS3--21940
SMPD1--124037
CDK5RAP1--24534
GBA--124709
CAV1--124767
AIDA--25079
CHORDC1--25131
DUSP22--25132
PLK1--25689

Network

GO:0071901

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HGNC: 9299  HPRD: 08912 
RGS4regulator of G-protein signaling 4 Entrez:5999  HGNC: 10000  HPRD: 03947  Ensembl: ENSG00000117152 
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) Entrez:7345  HPRD: 01877  HGNC: 12513  Ensembl: ENSG00000154277 
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1 Entrez:9479  HPRD: 05223  Ensembl: ENSG00000121653  HGNC: 6882 
NF1neurofibromin 1 Entrez:4763  HGNC: 7765  HPRD: 01203  Ensembl: ENSG00000196712 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4regulator of G-protein signaling 4
UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1
NF1neurofibromin 1
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4RGS4regulator of G-protein signaling 4
UCHL1UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
MAPK8IP1MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1
NF1NF1neurofibromin 1

Troyanskaya Laboratory - Princeton University