ASD

GO:0030837 negative regulation of actin filament polymerization (34)

GeneInput weightStandardRank
PFN2--431
SLIT2--582
CAPZB--953
SPTBN4--1223
DMTN--1226
TMSB10--1299
SPTBN2--11344
KANK1--1493
ADD2--1685
SPTAN1--12078
TMSB15A--2105
SPTB--2288
TMSB15B--2402
CAPZA2--2428
CAPZA1--2513
SPTA1--14158
TMSB4X--4291
CAPZA3--5405
RDX--15514
SPTBN5--5948
SPTBN1--8272
TMSB4Y--8925
ADD1--19458
AVIL--10360
CAPG--10638
SCIN--11105
TMSB4XP8--12337
TWF1--14449
TMSB4XP4--18618
TWF2--21814
GSN--122198
VIL1--22201
VILL--23074
TRIOBP--124727

Network

GO:0030837

Network
Enrichment
NameDescriptionExternal IDs
PFN2profilin 2 Entrez:5217  Ensembl: ENSG00000070087  HGNC: 8882  HPRD: 01451 
SLIT2slit homolog 2 (Drosophila) Entrez:9353  Ensembl: ENSG00000145147  HPRD: 04776  HGNC: 11086 
CAPZBcapping protein (actin filament) muscle Z-line, beta Entrez:832  HGNC: 1491  HPRD: 11872  Ensembl: ENSG00000077549 
SPTBN4spectrin, beta, non-erythrocytic 4 Entrez:57731  HPRD: 09372  HGNC: 14896  Ensembl: ENSG00000160460 
DMTNdematin actin binding protein Entrez:2039  HPRD: 00506  Ensembl: ENSG00000158856  HGNC: 3382 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PFN2profilin 2
SLIT2slit homolog 2 (Drosophila)
CAPZBcapping protein (actin filament) muscle Z-line, beta
SPTBN4spectrin, beta, non-erythrocytic 4
DMTNdematin actin binding protein
Query geneGeneGene descriptionEdge score
PFN2PFN2profilin 2
SLIT2SLIT2slit homolog 2 (Drosophila)
CAPZBCAPZBcapping protein (actin filament) muscle Z-line, beta
SPTBN4SPTBN4spectrin, beta, non-erythrocytic 4
DMTNDMTNdematin actin binding protein

Troyanskaya Laboratory - Princeton University