ASD

GO:0032320 positive regulation of Ras GTPase activity (84)

GeneInput weightStandardRank
SFRP1--204
RASGRF1--213
NF10.251333
MAP2K10.251474
JUN--647
SIPA1L1--893
THY1--993
RAPGEF2--1064
DLC1--1105
ARHGAP5--1129
NDEL10.2511194
RABGAP1L--1270
GSK3B--1592
ARHGAP35--1706
TSC10.2511844
DOCK40.2512053
PREX1--2219
RALGAPA1--2363
PREX2--2459
RASAL2--2472
RANGAP1--2553
FZD10--2606
CDKL5--12680
RHOG--2753
TBC1D10B--2796
S1PR1--2910
RASAL1--3061
SOS1--13181
PTK2B--3191
ARHGAP26--13447
DAB2IP--3635
SYNGAP10.2513673
ARHGAP1--3707
RASA1--4166
MYO9B--4244
ARHGAP6--4472
WNT11--4528
ARHGAP29--4961
FOXJ1--5202
HTR2B--5233
ARAP3--6203
CXCL13--6358
GRHL3--6732
RALGAPA2--6758
CCL11--7037
RASGRP3--7172
ERRFI1--7414
PIN1--8222
TAX1BP3--8734
SYDE1--9488
RALBP1--10248
SYDE2--10285
CCL19--11890
TBC1D15--12177
ALS2--112325
ARHGAP8--12529
ARHGEF19--12571
RASAL3--13407
RASA4--13696
EPHA2--114150
ALDH1A1--14295
ARHGAP15--14909
RASA2--15169
OPHN10.5116404
CCL24--17974
CCL21--19130
CDC42EP2--19516
CCL26--19975
GPR65--20238
ARHGEF16--20461
DOCK7--20528
RASA3--20776
CCR7--21314
ARHGAP4--21597
GMIP--22058
SIPA1--22102
RAB3GAP1--22229
ARHGEF10L--22238
NCKAP1L--23440
TBC1D2--23630
ARHGAP27--24221
RALGAPB--24333
SCRIB--24455
ARAP1--25493

Network

GO:0032320

Network
Enrichment
NameDescriptionExternal IDs
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 1 Entrez:5923  HGNC: 9875  Ensembl: ENSG00000058335 
NF1neurofibromin 1 Entrez:4763  HGNC: 7765  HPRD: 01203  Ensembl: ENSG00000196712 
MAP2K1mitogen-activated protein kinase kinase 1 Entrez:5604  HGNC: 6840  HPRD: 01469 
JUNjun proto-oncogene Entrez:3725  HGNC: 6204  HPRD: 01302  Ensembl: ENSG00000177606 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SFRP1secreted frizzled-related protein 1
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 1
NF1neurofibromin 1
MAP2K1mitogen-activated protein kinase kinase 1
JUNjun proto-oncogene
Query geneGeneGene descriptionEdge score
SFRP1SFRP1secreted frizzled-related protein 1
RASGRF1RASGRF1Ras protein-specific guanine nucleotide-releasing factor 1
NF1NF1neurofibromin 1
MAP2K1MAP2K1mitogen-activated protein kinase kinase 1
JUNJUNjun proto-oncogene

Troyanskaya Laboratory - Princeton University