ASD

GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (55)

GeneInput weightStandardRank
SFRP1--204
NR3C1--463
PEG10--540
TRIM33--1692
CHRD--697
SMAD7--1283
FBN2--1425
ONECUT2--1475
STRAP--1862
SMAD6--2079
HIPK2--2306
LEMD3--12358
NKX2-1--2488
SOSTDC1--2578
GREM1--2654
WNT5A--2870
WNT1--3263
BMPER--3267
NOTCH1--13360
SFRP2--3758
SKIL--4016
SKI--4231
ADAMTSL2--4249
SMURF1--4696
CER1--5192
CIDEA--5234
TGFB3--15321
BCL9L--5421
SOST--5795
PRDM16--5921
FBN1--16138
DKK1--6892
CHST11--7380
BAMBI--7548
NOG--17650
FST--8021
PIN1--8222
TGFBR3--8717
ASPN--10001
VWC2--10359
ACVR1--111780
DAND5--12393
SKOR2--13004
HSPA5--13639
SKOR1--16408
ENG--117647
FZD1--22086
EID2--22443
GLG1--22724
TGFB1I1--22730
SNX6--22785
LTBP1--23598
FSTL3--24700
CAV1--124767
TWSG1--25171

Network

GO:0090101

Network
Enrichment
NameDescriptionExternal IDs
SFRP1secreted frizzled-related protein 1 Entrez:6422  HPRD: 09165  Ensembl: ENSG00000104332  HGNC: 10776 
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Entrez:2908  HPRD: 00679  HGNC: 7978  Ensembl: ENSG00000113580 
PEG10paternally expressed 10 Entrez:23089  Ensembl: ENSG00000242265  HGNC: 14005 
TRIM33tripartite motif containing 33 Entrez:51592  HPRD: 10423  HGNC: 16290  Ensembl: ENSG00000197323 
CHRDchordin Entrez:8646  Ensembl: ENSG00000090539  HGNC: 1949  HPRD: 04592 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
SFRP1secreted frizzled-related protein 1
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PEG10paternally expressed 10
TRIM33tripartite motif containing 33
CHRDchordin
Query geneGeneGene descriptionEdge score
SFRP1SFRP1secreted frizzled-related protein 1
NR3C1NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PEG10PEG10paternally expressed 10
TRIM33TRIM33tripartite motif containing 33
CHRDCHRDchordin

Troyanskaya Laboratory - Princeton University