GO:0043409 negative regulation of MAPKKK cascade (66)

GeneInput weightStandardRank
PPP2CA--20
RGS4--178
IGF1R--252
APC0.251266
NF10.251372
DUSP8--438
MAPK8IP1--1605
SPRED2--811
SPRED1--962
NCOR1--1019
AKT10.2511020
PPP2R1A--1163
SPRY2--1454
DUSP5--2022
GPS1--2023
PSMD10--2412
DUSP6--2466
IGF10.2512793
ITCH--2932
TAOK3--3466
DAG1--3580
KLF4--3609
DUSP1--3785
FOXO10.2513947
DUSP4--4019
MEN1--14917
MECOM--4979
DUSP10--5172
DUSP16--5189
NF2--15991
ADIPOQ0.2516032
DUSP19--6060
SFRP4--7310
PPEF2--7509
P2RX7--7888
PIN1--7940
DUSP3--8506
DUSP2--8596
DUSP7--8625
GSTP10.2518742
LAX1--10483
SPRY1--10636
ZNF675--11676
SPRED3--12062
TLR4--112795
RGS14--12999
DUSP9--13685
MBIP--14010
CAV3--115414
PEBP1--15772
GPS2--17956
CNKSR3--19160
NDRG2--19677
F2RL1--19969
AMBP--20003
VRK3--20233
FKTN--120500
HDAC3--21702
SLC9A3R1--21898
LIF--22134
RGS3--23349
DUSP22--24825
IGBP1--25127
AIDA--25211
CAV1--125381
FOXM1--25656

Network

GO:0043409

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HPRD: 08912  HGNC: 9299 
RGS4regulator of G-protein signaling 4 Entrez:5999  HPRD: 03947  HGNC: 10000  Ensembl: ENSG00000117152 
IGF1Rinsulin-like growth factor 1 receptor Entrez:3480  HGNC: 5465  HPRD: 00932  Ensembl: ENSG00000140443 
APCadenomatous polyposis coli Entrez:324  HPRD: 01439  HGNC: 583  Ensembl: ENSG00000134982 
NF1neurofibromin 1 Entrez:4763  HPRD: 01203  HGNC: 7765  Ensembl: ENSG00000196712 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4regulator of G-protein signaling 4
IGF1Rinsulin-like growth factor 1 receptor
APCadenomatous polyposis coli
NF1neurofibromin 1
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4RGS4regulator of G-protein signaling 4
IGF1RIGF1Rinsulin-like growth factor 1 receptor
APCAPCadenomatous polyposis coli
NF1NF1neurofibromin 1