GO:0019932 second-messenger-mediated signaling (312)

GeneInput weightStandardRank
GNAO1--4
PPP2CA--20
GNB1--24
CNR10.25129
CREB1--100
HTR2A0.251121
PIK3R10.251150
ADCY2--175
GNAQ--189
GRM50.251240
SSTR2--251
IGF1R--252
RIMS2--282
PHLPP1--332
GSK3B--427
ADCY10.251466
RICTOR--537
RAPGEF2--540
PRKACB--584
CRHR1--589
APLP1--591
NPY0.251592
ITPR1--1597
HTR1E0.251695
HDAC4--696
CCKBR--794
GNAZ--856
DRD10.251899
RAPGEF40.251904
NTSR2--920
RYR2--1959
ADORA1--960
SOX9--1970
GRM10.251975
OPRK10.251996
CALCA--1013
AKT10.2511020
NPY2R0.2511024
CAMKK2--1053
FOXO3--1056
ADRB1--1057
DRD50.2511103
CDKN1B--1162
PPP2R1A--1163
GNAL--1177
NPY1R0.2511190
PI4KA--1242
GRIK30.2511247
GNAI3--1262
ADCYAP1R1--1273
BAD--1290
IRS2--11300
FZD7--1357
PIK3CA0.2511362
IRS1--11374
PTEN1.011389
FSHR--11398
ADRA2A0.2511399
HRH3--1428
GNAI1--1468
RPS6KB1--1521
RCAN2--1540
EDN3--11577
PTGER3--1587
PDPK1--1740
GNG13--1774
GNAS--11842
ADCY9--1850
ADRA1A--1858
HCRTR20.2511860
SPECC1L--1912
AGTR20.2511955
SSTR1--1959
PTHLH--11993
PI4KB--2004
NMBR--2016
EDNRB--12042
EPHA5--2077
PLCH1--2174
OPRM10.2512212
GNA11--2281
RHOA--2292
FKBP1B--2346
HTR70.2512365
CALCR--2381
EGFR--12546
HTR5A0.2512606
NCS1--2628
PCNA--2671
ADCY8--2785
IGF10.2512793
CHRM2--2799
ADCY6--2877
MCHR10.2512905
ADRB3--12953
CASQ1--2959
LHCGR0.2513057
FZD3--3193
CKS2--3213
HTR1A0.2513315
HMGB2--3362
TSHR--3382
HOMER10.2513402
GAB2--3496
GNA14--3634
CHRM50.2513694
PIK3C2G--3730
DRD20.2513749
RXFP1--3767
PI4KAP1--3784
MC2R--3795
AVPR1A0.513803
GNAT3--3827
HTR1F--3836
MC4R0.2513850
EDNRA--13857
FOXO10.2513947
HTR60.2514100
GSK3A--4141
HTR4--4168
LPAR1--4170
GHRHR--4237
FLNA--14285
ADCY5--4295
S1PR1--4301
P2RY1--4342
DRD30.2514349
CALCRL0.2514392
PIK3C2A--4475
MCTP1--4524
GRK5--4595
PTH1R--4648
GPR143--14685
P2RY12--4729
DGKD--4786
MTNR1A0.2514922
ADRA1B0.2514946
MC5R--4977
MLST8--5028
CCR3--5157
GCG--5190
PIK3R2--5198
NUDT4--5300
GPR3--5301
HIST1H4C--5314
PIK3C2B--5320
NPR3--5370
CHRM4--5408
GNAT2--5443
HIST1H4F--5483
GLP2R--5519
CRHR2--5751
ADCY3--5755
GNAI2--5860
RXFP2--15887
GALR1--5908
OPRD10.2516030
NGF0.2516229
OPRL10.2516271
AGTR1--16275
MTNR1B0.2516286
NMUR2--6430
XCR1--6470
MDM2--6675
GNA13--6683
S1PR3--6774
CHRM1--6796
GCGR--16828
PLCE1--6929
PTH--6947
HTR2B--6992
RXFP3--6996
DRD40.2517021
HIST1H4B--7028
AVPR2--17031
CASR--7200
CA8--7267
P2RY4--7298
GRM4--7321
HRH1--7471
GHRH--7478
GPRC6A--7662
CDKN1A--7714
LACRT--7733
HTR1D0.2517763
ADRA1D--7837
MC1R--17999
ITPR2--8066
HTR1B0.2518092
MC3R0.2518188
GPR26--8197
GPR139--8207
ADORA2A0.2518408
NTRK10.2518522
AVPR1B0.2518546
HIST1H4A--8765
HIST1H4E--8846
PDE7A--8858
ADCY4--9091
VIPR10.2519277
HIST4H4--9288
TSC20.2519351
PIK3C3--9358
FOXO4--9362
KISS1R--9434
EDN1--9540
HIST1H4I--9593
F2RL3--9626
GLP1R--9893
BHLHA15--9905
SSTR4--9920
PIK3CG0.25110306
GIPR--10369
HRH2--10518
RGS1--10535
UCN3--10665
MCTP2--10728
PI4KAP2--10862
PTGDR2--10914
PDZD3--11066
HIST1H4K--11490
CYTH3--11531
PIK3CB--11542
TACR1--11618
HCRT0.25111633
CNR20.25111649
CCKAR--11747
TREML1--11807
HIST1H4H--11835
LPAR3--11897
HIST2H4B--12217
HIST1H4L--12237
WASF2--12417
NR4A1--12498
CORT--12689
AGT--113305
AKT1S1--13569
GNA12--14481
SELE--14642
EIF4EBP2--14825
SSTR50.25114876
GALR2--14926
PTGER4--15180
TNF0.25115243
ADM2--15255
CXCR2--15438
HIST1H4D--15824
IL8--15864
FZD2--16930
ZP3--17443
SSTR3--18309
EDN2--18677
RCAN1--18854
NMUR1--19043
INSL3--119059
TBXA2R--19479
RCAN3--19521
FZD6--19921
LTB4R--19987
GNAT1--119999
F2R--20036
MAPKAP1--20094
EIF2AK3--20456
P2RY11--20669
FZD1--20775
TRIB3--20863
GNA15--20926
GPR78--20984
LAT--20987
CASP90.25121044
MTOR--21095
ADM--21106
FPR1--21375
HIST1H4J--21464
PTGIR0.25121564
PIK3CD--21578
ITPR3--21697
CCR1--21851
SLC9A3R1--21898
S1PR4--22105
BTK--122251
PLA2G4B--22374
NDUFS4--122766
MCU--22796
HIST2H4A--22838
P2RY6--23098
ERBB2--123130
TGM2--23204
CCL2--23209
RPS6KB2--23226
ADRB20.25123251
APOE0.25123516
CD36--23662
NDC80--23746
RFC4--23796
GSN--124007
THEM4--24011
SPHK1--24069
P2RY2--24088
LAT2--24455
CHUK--24756
TOP2A--24765
PTAFR--24788
TBL3--24834
ZWINT--25100
TYMS--25226
ADCY7--25408
SPAG5--25573
UBE2C--25614
FEN1--25667
BUB1B--125766
AURKA--125772

Network

GO:0019932

Network
Enrichment
NameDescriptionExternal IDs
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Entrez:2775  HGNC: 4389  HPRD: 00757  Ensembl: ENSG00000087258 
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HPRD: 08912  HGNC: 9299 
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1 Entrez:2782  HPRD: 00766  HGNC: 4396  Ensembl: ENSG00000078369 
CNR1cannabinoid receptor 1 (brain) Entrez:1268  HPRD: 00259  HGNC: 2159  Ensembl: ENSG00000118432 
CREB1cAMP responsive element binding protein 1 Entrez:1385  HPRD: 00442  HGNC: 2345  Ensembl: ENSG00000118260 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
CNR1cannabinoid receptor 1 (brain)
CREB1cAMP responsive element binding protein 1
Query geneGeneGene descriptionEdge score
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
GNB1GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
CNR1CNR1cannabinoid receptor 1 (brain)
CREB1CREB1cAMP responsive element binding protein 1