GO:0000165 MAPKKK cascade (226)

GeneInput weightStandardRank
KRAS--157
HTR2C0.25162
CREB1--100
YWHAB0.251107
HTR2A0.251121
MAPK10--1162
FGF12--263
RPS6KA5--359
NF10.251372
MAPK8IP2--418
MEF2C0.251428
MAP3K9--462
JUN--511
RET--1524
MAP3K12--533
RB1CC1--1534
RAPGEF2--540
SPAG9--558
MAP2K4--567
MAPK8IP1--1605
MINK1--606
FGF14--1668
RPS6KA20.251689
KIDINS220--701
RPS6KA3--758
MADD--759
TAB2--785
CCKBR--794
POU4F2--819
FGF13--870
MAP2K10.251907
GNG3--927
ADORA1--960
SOX9--1970
GRM10.251975
CAMKK2--1053
MAPK1--1128
GAB1--1198
DOK5--1213
MAPK8--1214
MAP3K5--1220
MAP2K20.2511240
MAP3K7--1275
ATF2--1309
SCG2--1369
ADRA2A0.2511399
TNIK--1531
TAOK20.2511633
FOS--1680
CHRNA70.511837
SMAD1--1872
TGFA--1873
CARTPT0.2511957
MAPK11--1962
PKN1--1967
GPS1--2023
ELK1--2032
MAPK9--2237
FGFR1--2262
MAPK8IP3--2274
DUSP6--2466
FGFR3--12640
MAPKBP1--2654
SOD1--12702
CRK--2713
MEF2A--2837
MAP3K13--2864
MAP4K5--2894
MAP3K10--2968
SH2D3C--3047
PTK2B--3063
CRKL--3156
MAP3K2--3184
RAF10.2513236
WNT5A--3319
MAP3K1--13381
TRIB1--3431
TAOK3--3466
DAB2IP--3482
TAB3--3641
MAP3K4--3663
MAP3K3--3713
MAPKAPK2--3870
FLT10.2513953
MAPK14--3975
DUSP4--4019
RBM4--4069
PDE6H--4126
LPAR1--4170
MAPK7--4384
AXIN1--14419
FGF10--14532
PROK2--14655
MEN1--14917
MAP2K5--4962
HRAS0.2515086
NDST1--5114
CCR3--5157
DUSP10--5172
HGF0.2515313
CXCR4--5414
MAP4K3--5481
PRDX2--5497
TNFRSF19--5520
PPM1L--5788
MAP2K7--5837
GNAI2--5860
INSR--15872
PLA2G1B--6059
DUSP19--6060
TDGF1--6132
ITPKB--6178
NGF0.2516229
OXTR0.516388
MAPK30.2516426
LPAR2--6450
BMP4--16499
UBC--6756
DOK4--6807
PLCE1--6929
HTR2B--6992
DRD40.2517021
WNT7B--7113
FRS2--7173
TAB1--7218
TGFBR1--17268
WNT7A--7312
GRM4--7321
FGD4--17457
NPHS1--7618
RAPGEF1--7926
MET1.018002
GADD45B--8312
RASGRP3--8406
DUSP3--8506
DAXX--8508
NTRK10.2518522
ADRA2C--8551
DUSP7--8625
LAMTOR2--8770
LRRK2--18802
PROK1--9002
GHRL0.2519242
KISS1R--9434
CCL11--9615
CDC42EP5--9805
C1QTNF2--10034
SHC1--10045
GHR--110098
ADRA2B--10119
MAP2K6--10478
IL1B--110818
TRAF6--11055
BRAF--111149
PIK3CB--11542
IL31RA--11821
LPAR3--11897
CD81--112160
EPGN--12503
TLR4--112795
EGF0.25112881
MAP3K11--12938
RAP1A--13091
TGFB3--113097
FGF2--13150
AGT--113305
AVP--113439
MDFI--13519
DUSP9--13685
MAP2K3--13704
MBIP--14010
NRAS--114119
NRTN--14223
CCL19--14578
IRAK2--15024
TNF0.25115243
ITGA1--15500
GPS2--17956
PSEN1--18523
TP73--18810
ARHGEF6--19241
IQGAP3--19438
UBB--19448
ADORA2B--19522
BIRC7--19826
F2R--20036
PTPLAD1--20272
PDE6G--120364
MAP4K2--20522
RIPK2--20830
C5AR1--21363
FPR1--21375
EFNA1--21477
NOD2--121514
IRAK1--21640
MDFIC--21692
ADAM8--21797
C5--122004
INS--122047
MAP4K1--22336
DBNL--22402
S1PR2--22592
RIPK1--22681
CCM2--22768
PRKAA1--22917
MUL1--22953
IRAK4--23154
RPS6KA1--23184
NOD1--23388
SH2D3A--23424
STRADB--23510
IKBKG--123539
AVPI1--23843
SYK--23906
CD74--24030
MAPKAPK3--24170
MAP3K6--24220
ATF1--24277
BRAP--24355
RPS27A--24381
UBA52--24384
THBS1--24444
CRYAB--124965
CDK1--25053
ADAM9--125221
ITGAV--25460

Network

GO:0000165

Network
Enrichment
NameDescriptionExternal IDs
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  HPRD: 01817  HGNC: 6407  Ensembl: ENSG00000133703 
HTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Entrez:3358  HPRD: 02429  HGNC: 5295  Ensembl: ENSG00000147246 
CREB1cAMP responsive element binding protein 1 Entrez:1385  HPRD: 00442  HGNC: 2345  Ensembl: ENSG00000118260 
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HPRD: 03184  HGNC: 12849  Ensembl: ENSG00000166913 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HGNC: 5293  HPRD: 01638  Ensembl: ENSG00000102468 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
KRASKirsten rat sarcoma viral oncogene homolog
HTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
CREB1cAMP responsive element binding protein 1
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Query geneGeneGene descriptionEdge score
KRASKRASKirsten rat sarcoma viral oncogene homolog
HTR2CHTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
CREB1CREB1cAMP responsive element binding protein 1
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled