GO:0043407 negative regulation of MAP kinase activity (57)

GeneInput weightStandardRank
PPP2CA--20
RGS4--178
NF10.251372
DUSP8--438
MAPK8IP1--1605
UCHL1--1675
SPRED2--811
SPRED1--962
BMP7--1137
PPP2R1A--1163
SPRY2--1454
DUSP5--2022
GPS1--2023
DUSP6--2466
HMGCR--2526
PDCD4--2707
SPRY4--3196
DAB2IP--3482
DUSP1--3785
DUSP4--4019
INPPL1--4681
RGS2--5095
DUSP10--5172
DUSP16--5189
ADIPOQ0.2516032
DUSP19--6060
BMP4--16499
PRKCD--6504
HIPK3--8282
DUSP3--8506
DUSP2--8596
DUSP7--8625
GSTP10.2518742
NUP62--18755
PTPRJ--19136
TSC20.2519351
LAX1--10483
SPRY1--10636
IL1B--110818
ZNF675--11676
STK380.25111822
SPRED3--12062
RGS14--12999
DUSP9--13685
MBIP--14010
IRAK3--14633
CAV3--115414
GPS2--17956
TP73--18810
CBLC--21497
RGS3--23349
APOE0.25123516
GBA--123666
DUSP22--24825
SMPD1--125116
AIDA--25211
CAV1--125381

Network

GO:0043407

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HPRD: 08912  HGNC: 9299 
RGS4regulator of G-protein signaling 4 Entrez:5999  HPRD: 03947  HGNC: 10000  Ensembl: ENSG00000117152 
NF1neurofibromin 1 Entrez:4763  HPRD: 01203  HGNC: 7765  Ensembl: ENSG00000196712 
DUSP8dual specificity phosphatase 8 Entrez:1850  HPRD: 03617  HGNC: 3074  Ensembl: ENSG00000184545 
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1 Entrez:9479  HGNC: 6882  HPRD: 05223  Ensembl: ENSG00000121653 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4regulator of G-protein signaling 4
NF1neurofibromin 1
DUSP8dual specificity phosphatase 8
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4RGS4regulator of G-protein signaling 4
NF1NF1neurofibromin 1
DUSP8DUSP8dual specificity phosphatase 8
MAPK8IP1MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1