GO:0071901 negative regulation of protein serine/threonine kinase activity (77)

GeneInput weightStandardRank
PPP2CA--20
RGS4--178
APC0.251266
LRP6--279
NF10.251372
DUSP8--438
MAPK8IP1--1605
UCHL1--1675
SPRED2--811
SPRED1--962
BMP7--1137
CDKN1B--1162
PPP2R1A--1163
PTEN1.011389
SPRY2--1454
DUSP5--2022
GPS1--2023
ABL1--2404
DUSP6--2466
HMGCR--2526
PDCD4--2707
LATS1--2781
NR2F2--2941
SPRY4--3196
DAB2IP--3482
DUSP1--3785
DUSP4--4019
INPPL1--4681
MEN1--14917
RGS2--5095
DUSP10--5172
DUSP16--5189
MYOCD--5907
HEXIM1--5982
ADIPOQ0.2516032
DUSP19--6060
TFAP4--6377
BMP4--16499
PRKCD--6504
CDKN1A--7714
HIPK3--8282
DUSP3--8506
DUSP2--8596
DUSP7--8625
GSTP10.2518742
NUP62--18755
PTPRJ--19136
TSC20.2519351
LRP5--19420
LATS2--9736
LAX1--10483
SPRY1--10636
IL1B--110818
ZNF675--11676
STK380.25111822
SPRED3--12062
RGS14--12999
DUSP9--13685
MBIP--14010
IRAK3--14633
CAV3--115414
GPS2--17956
TP73--18810
CDKN2A--120587
CBLC--21497
HEXIM2--21545
RGS3--23349
APOE0.25123516
KAT2B--23529
GBA--123666
CDK5RAP1--24649
DUSP22--24825
SMPD1--125116
AIDA--25211
CHORDC1--25294
CAV1--125381
PLK1--25783

Network

GO:0071901

Network
Enrichment
NameDescriptionExternal IDs
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HPRD: 08912  HGNC: 9299 
RGS4regulator of G-protein signaling 4 Entrez:5999  HPRD: 03947  HGNC: 10000  Ensembl: ENSG00000117152 
APCadenomatous polyposis coli Entrez:324  HPRD: 01439  HGNC: 583  Ensembl: ENSG00000134982 
LRP6low density lipoprotein receptor-related protein 6 Entrez:4040  HPRD: 04617  HGNC: 6698  Ensembl: ENSG00000070018 
NF1neurofibromin 1 Entrez:4763  HPRD: 01203  HGNC: 7765  Ensembl: ENSG00000196712 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4regulator of G-protein signaling 4
APCadenomatous polyposis coli
LRP6low density lipoprotein receptor-related protein 6
NF1neurofibromin 1
Query geneGeneGene descriptionEdge score
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
RGS4RGS4regulator of G-protein signaling 4
APCAPCadenomatous polyposis coli
LRP6LRP6low density lipoprotein receptor-related protein 6
NF1NF1neurofibromin 1