GO:0019932 second-messenger-mediated signaling (312)

GeneInput weightStandardRank
GNAO1--3
CNR10.25110
GNB1--15
PPP2CA--21
HTR2A0.25151
ADCY2--102
SSTR2--185
GRM50.251196
RIMS2--273
CRHR1--280
AKT10.251303
APLP1--335
HTR1E0.251415
NPY0.251456
CALCA--460
ADCY10.251466
DRD50.251482
GNAQ--490
NTSR2--493
ADORA1--498
PHLPP1--505
GRM10.251523
CCKBR--533
PRKACB--544
NPY2R0.251597
GNAZ--618
IGF1R--631
RAPGEF40.251635
FSHR--1648
DRD10.251662
OPRK10.251764
ITPR1--1802
PTGER3--842
PPP2R1A--852
GNAL--860
RYR2--1862
ADRB1--866
ADRA1A--937
CAMKK2--954
HDAC4--963
RHOA--973
GRIK30.251976
FLNA--1984
CREB1--991
NPY1R0.2511012
SOX9--11045
RCAN2--1048
IRS1--11052
RAPGEF2--1064
PIK3R10.2511065
CDKN1B--1067
RICTOR--1074
HCRTR20.2511101
ADCYAP1R1--1132
HRH3--1240
PTHLH--11269
EDNRB--11322
GNAI3--1340
HMGB2--1353
EPHA5--1409
AGTR20.2511418
NMBR--1448
HTR5A0.2511507
EDN3--11522
HTR70.2511529
ADRA2A0.2511556
PCNA--1558
GSK3B--1592
IRS2--11607
GNAI1--1613
BAD--1647
HTR1A0.2511672
PLCH1--1697
FKBP1B--1700
GNG13--1713
PI4KA--1721
SSTR1--1732
ADRB3--11787
ADCY8--1906
MC2R--1919
IGF10.2511993
MCHR10.2512005
DRD20.2512071
HTR60.2512191
CHRM2--2223
CALCR--2247
PTEN1.012260
CHRM50.2512290
GHRHR--2312
GSK3A--2346
GNAS--12352
LHCGR0.2512362
NCS1--2387
ADCY9--2435
CASQ1--2466
OPRM10.2512614
HTR1F--2699
FZD7--2714
DRD30.2512757
RPS6KB1--2773
PIK3CA0.2512782
HTR4--2810
EGFR--12811
CKS2--2880
GNAT3--2884
AGTR1--12898
RXFP1--2904
S1PR1--2910
FOXO3--2950
LPAR1--2975
SPECC1L--3048
TSHR--3078
PIK3C2G--3097
PTH1R--3098
GPR143--13103
AVPR1A0.513141
GNA11--3167
PI4KB--3221
CALCRL0.2513258
OPRD10.2513266
EDNRA--13271
MC4R0.2513280
MC5R--3358
GCGR--13430
GNA14--3434
CRHR2--3445
FZD3--3579
P2RY12--3680
NGF0.2513749
ADRA1D--3761
AGT--13783
NPR3--3798
MTNR1B0.2513826
GAB2--3859
GNAT2--3923
MTNR1A0.2514011
PDPK1--4150
GLP2R--4213
GCG--4286
ADCY5--4352
ADCY6--4362
GPR3--4384
CHRM4--4460
P2RY1--4483
AVPR1B0.2514502
AVPR2--14537
GHRH--4568
GRK5--4585
ADCY3--4618
CDKN1A--4620
MCTP1--4642
CASR--4724
CCR3--4859
NTRK10.2514883
HIST1H4F--4902
NUDT4--5056
HTR2B--5233
RXFP3--5237
P2RY4--5261
HRH1--5298
XCR1--5374
PTH--5481
PIK3R2--5501
MDM2--5588
PIK3C2A--5651
HTR1B0.2515751
GRM4--5804
NMUR2--5836
GALR1--5954
ADRA1B0.2515964
GPR26--6001
PI4KAP1--6091
HOMER10.2516115
DGKD--6199
GPRC6A--6222
MC3R0.2516322
RXFP2--16360
GNAI2--6384
HIST1H4B--6463
S1PR3--6584
CHRM1--6680
LACRT--6955
FOXO10.2516970
DRD40.2517058
PIK3C2B--7094
HTR1D0.2517287
GLP1R--7291
RGS1--7315
HCRT0.2517434
F2RL3--7474
MLST8--7510
CCKAR--7616
TACR1--7688
PLCE1--7692
CA8--7847
KISS1R--8159
OPRL10.2518293
MC1R--18333
ADCY4--8354
CNR20.2518581
ITPR2--8681
PIK3CG0.2518744
HIST1H4C--8810
PIK3C3--8907
HIST1H4L--9008
SSTR50.2519084
IL8--9093
GIPR--9148
HIST1H4E--9376
HRH2--9388
PTGDR2--9477
EDN1--9566
TREML1--9603
ADORA2A0.2519605
RCAN1--9640
HIST1H4A--9720
UCN3--9836
PIK3CB--10067
HIST4H4--10081
HIST1H4I--10206
VIPR10.25110225
FOXO4--10242
PTGER4--10436
LPAR3--10488
SELE--10573
SSTR4--10595
ADM--10761
GNA12--10962
NR4A1--11126
CORT--11364
TSC20.25111448
CXCR2--11514
HIST1H4D--11522
CHUK--11526
INSL3--111614
HIST1H4H--11763
GPR139--11802
SSTR3--12043
HIST1H4K--12218
PDZD3--12463
F2R--12498
GNAT1--112585
MCTP2--12646
GALR2--12784
AKT1S1--12840
HIST2H4B--12893
CCR1--13007
NMUR1--13186
EDN2--13347
PI4KAP2--13628
TGM2--13660
BHLHA15--13923
FZD2--13981
FPR1--14197
CCL2--14604
ADM2--15430
MTOR--15435
TBXA2R--15453
CYTH3--15556
ZP3--15811
TRIB3--16821
PTGIR0.25117719
P2RY11--18359
GPR78--19507
PIK3CD--19521
WASF2--19696
TNF0.25119823
FZD6--19825
GNA15--20239
MAPKAP1--20345
GNA13--20348
EIF2AK3--20407
EIF4EBP2--20602
BTK--120625
NDUFS4--121018
PDE7A--21279
APOE0.25121310
LTB4R--21535
SPHK1--21548
HIST1H4J--21610
ERBB2--121638
SLC9A3R1--21807
P2RY6--21915
MCU--21953
FZD1--22086
GSN--122198
ITPR3--22312
S1PR4--22365
RPS6KB2--22371
HIST2H4A--22387
RCAN3--22548
LAT--22661
CASP90.25122672
ADRB20.25122718
CD36--22749
RFC4--22834
NDC80--23060
TYMS--23100
PLA2G4B--23796
THEM4--23999
P2RY2--24073
TOP2A--24163
LAT2--24209
TBL3--24403
ZWINT--24503
PTAFR--24817
FEN1--25085
ADCY7--25198
UBE2C--25279
SPAG5--25440
BUB1B--125795
AURKA--125803

Network

GO:0019932

Network
Enrichment
NameDescriptionExternal IDs
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Entrez:2775  HGNC: 4389  HPRD: 00757  Ensembl: ENSG00000087258 
CNR1cannabinoid receptor 1 (brain) Entrez:1268  HPRD: 00259  HGNC: 2159  Ensembl: ENSG00000118432 
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1 Entrez:2782  HPRD: 00766  HGNC: 4396  Ensembl: ENSG00000078369 
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme Entrez:5515  HPRD: 08912  HGNC: 9299 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HGNC: 5293  HPRD: 01638  Ensembl: ENSG00000102468 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
CNR1cannabinoid receptor 1 (brain)
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
Query geneGeneGene descriptionEdge score
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
CNR1CNR1cannabinoid receptor 1 (brain)
GNB1GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1
PPP2CAPPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled