GO:0000165 MAPKKK cascade (226)

GeneInput weightStandardRank
YWHAB0.25145
HTR2C0.25146
HTR2A0.25151
KRAS--1143
FGF12--181
MAPK10--1194
MEF2C0.251248
MAPK8IP2--275
RB1CC1--1279
MAPK8IP1--1326
NF10.251333
RET--1384
MAP2K10.251474
ADORA1--498
MAP3K9--500
FGF14--1522
GRM10.251523
CCKBR--533
POU4F2--535
MAP2K4--579
GNG3--591
MAP3K12--592
FGF13--626
JUN--647
RPS6KA5--677
RPS6KA20.251711
MINK1--777
SCG2--849
RPS6KA3--861
DOK5--897
MADD--898
CAMKK2--954
MAPK1--985
CREB1--991
SOX9--11045
RAPGEF2--1064
MAP2K20.2511066
ATF2--1137
CARTPT0.2511181
MAP3K5--1245
MAPK11--1258
ELK1--1329
KIDINS220--1337
SPAG9--1398
TNIK--1544
ADRA2A0.2511556
TGFA--1563
FGFR3--11648
CHRNA70.511657
MAPK8--1764
MAP3K10--1767
CD81--11828
FOS--1839
GAB1--1864
DUSP6--1889
PKN1--1964
GPS1--2030
MAP3K7--2169
FLT10.2512278
MAPK9--2324
TAOK20.2512490
MAPK8IP3--2496
FGFR1--2550
TAB2--2777
SMAD1--2829
MAP3K13--2868
WNT5A--2870
LPAR1--2975
PTK2B--3191
PDE6H--3301
SH2D3C--3315
SOD1--13330
TRIB1--3331
MAPKAPK2--3441
MET1.013618
DAB2IP--3635
PROK2--13667
MAPKBP1--3672
NGF0.2513749
AGT--13783
CXCR4--4014
HGF0.2514189
DUSP4--4300
FGF10--14373
PLA2G1B--4440
TAOK3--4471
CRK--4478
OXTR0.514494
MAP2K5--4533
MAPK7--4626
MAPK14--4729
MAP4K3--4763
CCR3--4859
NTRK10.2514883
MAP4K5--4887
DUSP19--5073
BMP4--15180
HTR2B--5233
TGFB3--15321
NRAS--15506
RAF10.2515559
UBC--5781
NDST1--5799
GRM4--5804
SHC1--5839
DUSP3--5845
GADD45B--6021
TGFBR1--16027
MEF2A--6060
MAPK30.2516096
DUSP10--6196
IL1B--16220
CRKL--6254
WNT7A--6375
GNAI2--6384
TAB3--6412
MAP3K3--6498
TNFRSF19--6510
ADRA2C--6524
MAP3K4--6590
PPM1L--6683
MEN1--16723
MAP3K1--16751
TDGF1--6833
NPHS1--6850
CCL11--7037
DRD40.2517058
RASGRP3--7172
TLR4--17283
C1QTNF2--7354
DUSP7--7411
DUSP9--7653
PLCE1--7692
WNT7B--7693
RAP1A--7718
ITPKB--7886
KISS1R--8159
ADRA2B--8196
PROK1--8256
IL31RA--8296
RBM4--8366
MAP2K7--8382
EGF0.2518839
PRDX2--8945
MAP2K3--9005
IRAK1--9309
GHRL0.2519333
DOK4--9365
RAPGEF1--9624
FGF2--9627
DAXX--9639
TAB1--9783
MAP3K2--10013
GHR--110058
PIK3CB--10067
MAP2K6--10398
LPAR3--10488
MBIP--10795
AXIN1--110905
INSR--110986
ADORA2B--11164
IRAK2--11461
EPGN--11496
AVP--111615
FGD4--111677
MDFI--11799
LAMTOR2--11829
CCL19--11890
BIRC7--12220
CDC42EP5--12367
F2R--12498
FRS2--12610
BRAF--112672
HRAS0.25112845
ARHGEF6--13050
NRTN--13324
LRRK2--113335
RIPK2--13928
ITGA1--13957
IQGAP3--14020
FPR1--14197
DBNL--14433
LPAR2--14606
MDFIC--14627
TRAF6--14847
C5--115436
ATF1--15773
TP73--15964
C5AR1--16349
S1PR2--18246
INS--119021
TNF0.25119823
PDE6G--119831
PSEN1--20241
GPS2--20293
ADAM8--20729
CCM2--20854
MAP4K2--20924
STRADB--21620
EFNA1--21813
THBS1--21993
RPS6KA1--22219
UBB--22223
MAP4K1--22293
MUL1--22450
CD74--22633
NOD2--122677
PTPLAD1--22865
RPS27A--22920
RIPK1--23173
MAP3K11--23341
AVPI1--23367
IRAK4--23495
MAPKAPK3--23643
NOD1--23711
SYK--23795
IKBKG--123817
CDK1--24001
UBA52--24116
PRKAA1--24385
MAP3K6--24401
SH2D3A--24548
ADAM9--124801
CRYAB--124949
BRAP--25341
ITGAV--25348

Network

GO:0000165

Network
Enrichment
NameDescriptionExternal IDs
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Entrez:7529  HPRD: 03184  HGNC: 12849  Ensembl: ENSG00000166913 
HTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Entrez:3358  HPRD: 02429  HGNC: 5295  Ensembl: ENSG00000147246 
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Entrez:3356  HGNC: 5293  HPRD: 01638  Ensembl: ENSG00000102468 
KRASKirsten rat sarcoma viral oncogene homolog Entrez:3845  HPRD: 01817  HGNC: 6407  Ensembl: ENSG00000133703 
FGF12fibroblast growth factor 12 Entrez:2257  HPRD: 03303  HGNC: 3668 
GenesetTypeFreq. (Network vs Genome)P-Value (FDR Corrected)Genes
GeneDescriptionAvg. edge score to queryRankIn genesetIn query
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
KRASKirsten rat sarcoma viral oncogene homolog
FGF12fibroblast growth factor 12
Query geneGeneGene descriptionEdge score
YWHABYWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HTR2CHTR2C5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR2AHTR2A5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
KRASKRASKirsten rat sarcoma viral oncogene homolog
FGF12FGF12fibroblast growth factor 12